Topic
Calibration curve
About: Calibration curve is a research topic. Over the lifetime, 6552 publications have been published within this topic receiving 95128 citations.
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TL;DR: In this paper, the relation between intensity of muonic X-rays and elemental composition was examined by examining the relationship between X-ray intensity and the elemental composition of a bulk material.
Abstract: Quantitative elemental analysis method of a bulk material by examining the relation between intensity of muonic X-rays and elemental composition was developed. Using this new calibration method, we...
26 citations
TL;DR: The CEI-100 interface was more suited for the detection of carboplatin in our experimental set-up as discussed by the authors, and a relative detection limit of 21 µg Pt L−1 was found for the CEI100 interface.
Abstract: Two commercially available CE-ICP-MS interfaces were investigated with respect to precision, limits of detection and ease-of-use. Our results demonstrate that the CEI-100 interface was more suited for the detection of carboplatin in our experimental set-up. A relative detection limit of 21 µg Pt L−1 corresponding to an absolute detection limit of 0.1 fg Pt was found for the CEI-100 interface. The quantitative aspects of CE-ICP-MS were addressed and a method was developed using sodium diatrizoate as an internal standard added to the samples to correct for changes in sensitivity between runs. A significant improvement on the repeatability was obtained. The method was applied for the determination of free carboplatin in plasma incubations. The percentage of free carboplatin was calculated both based on the calibration curve and based on the fraction of free carboplatin relative to the total platinum area. Significantly different results were obtained using the two methods, probably due to adsorption of the plasma proteins to the incubation vial or to the capillary or due to formation of carboplatin adducts in concentrations below the limit of detection. This indicates a need for critical evaluation of the quantitative CE-ICP-MS measurements used for kinetic profiling.
26 citations
TL;DR: In this article, an exponential relationship between the external standard γ-source count rate and quencher concentration was obtained by properly selecting gain and discriminator settings for counting the external source.
26 citations
TL;DR: A polynomial regression was desired to describe the relationship between isotope ratios and mole ratios and was found to approximately describe the curvature of the calibration curve.
Abstract: Instead of artificially transforming the data to a linear model for the isotope dilution mass spectrometry (IDMS) curve, a polynomial regression was desired to describe the relationship between isotope ratios and mole ratios. The described calculation procedure was tested by applying it to synthetic data generated by the basic IDMS equation and was compared with actual data from an IDMS study of Bromhexine, a mucolytic drug (C/sub 14/H/sub 22/N/sub 2/Br/sub 2/), and its trideuterated analog. The model was found to approximately describe the curvature of the calibration curve.
26 citations
TL;DR: The HPLC method described here was simple, rapid and reproducible since it did not require extraction and evaporation processes in sample preparation, which will reduce time-consuming or expensive sample preparation.
26 citations