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Showing papers on "Cancer cell published in 1972"


Journal ArticleDOI
04 Feb 1972-Nature
TL;DR: The cell surface characteristics of the cell surface are most likely to be directly relevant to the altered response of cancer cells to control mechanisms.
Abstract: AMONG the many differences between normal and cancer cells those of the cell surface are most likely to be directly relevant to the altered response of cancer cells to control mechanisms1–10.

127 citations


Journal ArticleDOI
TL;DR: Three cancer cell strains that fail to make permeable membrane junctions were tested for ability to transfer an endogenous hypoxanthine derivative from cell to cell, and a contact-independent transfer phenomenon was observed with these three cancer cell strain.

90 citations


Journal ArticleDOI
09 Feb 1972-Nature
TL;DR: Preliminary studies demonstrating in vitro and in vivo a significant cytotoxic effect of rat peritoneal neutrophils against a syngeneic ascites tumour, WBP1(A), < 10 cells of which will produce a tumour are described.
Abstract: SPECIFIC immunological phenomena directed against tumour cells which influence their behaviour and growth in vivo and in vitro have been clearly established1,2. In contrast, nonspecific defences against cancer have received little attention, although such mechanisms are important in preventing microbial infection3. Recently there have been indications that such non-specific defences against cancer cells exist but the underlying processes are undefined. Increases in reticuloendothelial activity frequently occur during tumour growth4; stimulants of non-specific defences, such as the BCG strain of Mycobacterium tuberculosis and Corynebacterium parvum, inhibit tumour growth5,6; and induction of inflammation by vaccinia7 or dichloronitrobenzene8 in skin overlying a tumour may induce regression. Most attempts to analyse these phenomena implicate unsensitized lymphocytes9 and macrophages10, although the cytotoxic properties of these cells compared with specifically sensitized cells are low11. Little has been written about the possible role of neutrophils, although their presence in tumours is not infrequent12. The probable role of neutrophils in contributing to the cytotoxic activity in vitro of leucocyte populations towards various allogeneic and syngeneic cell types has been discussed13 and Bubenik et al.14 have postulated an action of neutrophils against human bladder tumours. Recently Godleski et al.15 showed movement of neutrophils towards cells of Walker carcinosarcoma 256 growing on chick chlorioallantoic membranes or cover-slips, followed by contact and damage to tumour cell membranes. This article describes preliminary studies demonstrating in vitro and in vivo a significant cytotoxic effect of rat peritoneal neutrophils against a syngeneic ascites tumour, WBP1(A), < 10 cells of which will produce a tumour16,17.

62 citations


Journal ArticleDOI
11 Oct 1972-Nature
TL;DR: A logical step would be to determine the subcellular localization of the specific antigen(s) on or within the cancer cell and whether or not the antigen continues to be associated with human malignant cells long maintained in culture.
Abstract: FOLLOWING the adventitious finding that lymphocytes from patients with malignant (but not benign) neoplasia are sensitized to encephalitogenic basic protein of myelin (EF)1 and to a protein similarly extracted from a variety of tumours2, a logical step would be to determine the subcellular localization of the specific antigen(s) on or within the cancer cell and whether or not the antigen continues to be associated with human malignant (or transformed) cells long maintained in culture. If this were so, then such cultures might serve as a convenient and standard source for an antigen of considerable potential in the diagnosis—and perhaps also the treatment—of malignant disease. The allied question of the identity and uniqueness of the antigens extractable from different cell lines or tumours will be the subject of a separate communication.

19 citations





Journal Article
TL;DR: Aspartyl-tRNA elution profiles were obtained from normal rat and hamster livers, Novikoff ascites hepatoma cells, and two different virus-induced hamster tumors, which exhibited a third, late eluting peak in the reverse-phase chromatography system.
Abstract: Aspartyl-tRNA elution profiles were obtained from normal rat and hamster livers, Novikoff ascites hepatoma cells, and two different virus-induced (SV40) hamster tumors. A characteristic two-peak pattern was observed consistently in studies of the normal livers or the ascites tumor cells. However, the virus-induced tumors exhibited a third, late eluting peak in the reverse-phase chromatography system.

14 citations


Journal ArticleDOI
TL;DR: An interaction between lymphocytes and cancer cells is an essential component in the defense against the growth of neoplastic cells in the human body.
Abstract: AN interaction between lymphocytes and cancer cells is an essential component in the defense against the growth of neoplastic cells in the human body.1 2 3 4 5 6 The ability of the lymphocyte to ad...

13 citations


Journal Article
TL;DR: The induction of chromatid translocations by 1-methyl-2-benzylhydrazine was studied in a number of malignant and normal mammalian cell types and in narcissus root cells, and no translocations were observed in treated or untreated normal tissues in vivo or in vitro.
Abstract: The induction of chromatid translocations by 1-methyl-2-benzylhydrazine was studied in a number of malignant and normal mammalian cell types and in narcissus root cells. In three different mouse ascites tumors (Ehrlich, 2BF, and L1210) treated in vivo , translocations were induced. In the Ehrlich tumor, they were induced with unusually high frequency, involving, in some cells, a majority of the chromosomes. None were found in the Ehrlich tumor or HeLa cells in vitro , nor were any found in untreated controls. No translocations were observed in treated or untreated normal tissues in vivo (mouse bone marrow and spleen, narcissus roots) or in vitro (human lymphocytes, mouse spleen).

13 citations



Journal ArticleDOI
TL;DR: The distinguishing property of the cancer cell is its capacity to multiply and invade in situations where normal cells are restricted, but there is no evidence that in a neoplasia the cells grow and divide by any other than the same rules and mechanisms by which cells grew and divide in any normal tissue or in any other situation.
Abstract: The distinguishing property of the cancer cell is its capacity to multiply and invade in situations where normal cells are restricted. The extraordinary research effort of the last decades to translate this primary difference be tween cancer and normal cells into unique and specific biochemical dif ferences is based on the very reasonable premise that the discovery of a unique biochemical property for all cancer cells is virtually an essential step in the even tual design of completely and absolutely specific anticancer chemotherapeutic agents.Unfortunately,theefforts to achievesuchtranslation have sofar largely failed, but in the course of this “¿ failure,― an enormous amount has been learned about cell chemistry, physiology and reproduction. We have learned to make a sharp distinction between abnormal cell repro duction and abnormal regulation of cell reproduction. The failure to recognize this difference has sometimes been a source of confusion, has inspired some fruitless research and has led to point less controversy. Neoplasia is defined as the formation of any new and abnormal growth,butthereisno evidencethat in a neoplasm the cells grow and divide by any other than the same rules and mechanisms by which cells grow and divide in any normal tissue or in any other situation (e.g., in culture). Thus, the abnormality in neoplasia is present not in the processes that con

Journal ArticleDOI
TL;DR: Cancer may be due to the destruction of a gene which controls the concentration of the surface active agent responsible for cell division, and cholesterol might be used to destroy cancer cells.

Journal ArticleDOI
Masahito Higuchi1, Kazuo Uemura1, Kosaku Eto1, Shoji Gohara1, Shinichi Hirata1 
TL;DR: The results are suggestive of the presence of the effects altering endocrinological medium on tumor formation, which was investigated by altering endocrine environments of the rats with this tumor.
Abstract: An increase in paper regarding eludidation of carcinogenic mechanism implies an importance of this problem. Especially, clarification of an interrelationship between carcinogenesis and change in hormonal evironments is of great interest, because hormone is a substance physiologically present in the body and it is possible to influence the states of the cancer cells. In this paper, the effect of hormones on prostate cancer was investigated by altering endocrine environments of the rats with this tumor. The rate of occurrence of prostate cancer and the ultrastructure of the tumor were examined. The following results were obtained. 1. The rate of occurrence of prostate tumor; The rates were 8.69 % in a group of the rats which were subcutaneouslly inoculated 20-MC wrapped with prostate tissue, 10 % in a group of the rats which were subcutaneously inoculated 4 - NQO wrapped with prostate tissue, 20 % in a group of the rats that 20 - MC was intraprostatically applied, and 12.5 % in a group of the rats that intraglandular injection of 20-MC was combined with castration. The rates were, on the other hand, 2.78 % in a group of the rats with castration and 8.89 % in a group of the rats without castration. The results are suggestive of the presence of the effects altering endocrinological medium on tumor formation. 2. Histological investigation; All the tumors provoked were leiomyoma. Electron microscopically, two types of cells, light and dark in electron density, were present intricately. The nuclei of the cells were irregular, and chromatin cluster was abundant in the nucleus. The ribosomes showed conspicuos rosette formation. The development of the Golgi complex was relatively good in the light cells but not good in the dark cells.



Journal ArticleDOI
TL;DR: The studies indicated that cancer cells are repidly removed by circulation through the liver, there is an increase in vascular resistance which is proportional to the number of cancer cells infused, and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.


Journal ArticleDOI
TL;DR: Cell cultures derived from a mammary adenocarcinoma carried in inbred Fisher (CDF) strain female rats, shown to possess oncogenic activities and on injection into control rats to produce mammary carcinomata, are found to have the capacity to reject injections of the untreated, active cancer cells.
Abstract: Cell cultures derived from a mammary adenocarcinoma carried in inbred Fisher (CDF) strain female rats, have been shown to possess oncogenic activities and on injection into control rats to produce mammary carcinomata with a failure rate of only one out of 25 rats (i.e. 4%). Efforts have been made to alter the cultured cells, or to select populations from them, so that the response in rats to their antigenic characteristics might leave them with the ability to then reject injections of the active, untreated cancer cells. We have found that continuous treatment of the cultures by their own cell debris (sonicate), or by relatively high concentrations of intact, salmon-sperm DNA, lead to cell populations which have a decreased potential to produce mammary carcinomata, with a combined failure rate of 9 out of 12 rats (i.e. 75%): 5 out of these 12 rats (i.e. 41·7%) did not exhibit any growth (carcinomata or granulomata) after injection of these treated cells, and now all 5 (i.e. 100%) have the capacity to reject injections of the untreated, active cancer cells. Four of these rats (one died under anaesthesia) have now been found to also reject implants of the carcinoma itself.