Topic
Carbazide
About: Carbazide is a research topic. Over the lifetime, 99 publications have been published within this topic receiving 932 citations.
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Patent•
07 Dec 1993
Abstract: The present invention provides methods and compounds for modifying polypeptides with PEG or other water-soluble organic polymers. Novel water-soluble polymer reagents are provided for. The water-soluble polymer reagents of the subject invention include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carbonic acid dihydrazide, carbazide, thiocarbazide, and arylhydrazide derivatives as well as oxylamine derivatives of water-soluble organic polymers, such as polyethylene glycol, polypropylene glycol, polyoxyethylated polyol, heparin, heparin fragments, dextran, polysaccharides, polyamino acids, and polyvinyl alcohol. Also provided for, are polypeptides of interest derivatized by the subject water-soluble polymer reagents. Kits for modifying polypeptides with the subject water-soluble polymer reagents are also provided.
155 citations
01 Jan 2011
TL;DR: In this article, a series of 1,4-dihydropyridine derivatives (1a-g) were prepared from Hantzsch syntheses, which were reacted with thiosemi- carbazide to give the new series of compounds 2a -g.
Abstract: A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from Hantzsch syntheses. The compounds 1a-g were reacted with thiosemi- carbazide to give the new series of compounds 2a-g. IR, 1 H-NMR, 13 C-NMR, mass spectral and elemental analysis confirmed the synthesized compounds. The synthesized compounds were also screened for their antimicrobial activity.
73 citations
TL;DR: In this paper, the corrosion inhibition of steel in phosphoric acid by thiosemi- carbazide derivatives has been studied using different chemical and electrochemical techniques, and the observed order of increasing inhibition efficiency was correlated with changes in the molecular structures of the inhibitors.
Abstract: The corrosion inhibition of steel in phosphoric acid by thiosemi- carbazide derivatives has been studied using different chemical and electrochemical techniques. The observed order of increasing inhibition efficiency was correlated with changes in the molecular structures of the inhibitors. Potentiodynamic po- larization curves indicate that the compounds are mixed-type inhibitors. Electrochemical impedance spectroscopy has been used successfully to evaluate the performance of the inhibitors. AC measurements showed that the dissolution process was activation-controlled. The kinetic- thermodynamic model and the Flory- Huggins adsorption isotherm described the experimental findings well. The number of active sites, binding constant and change in free energy were computed for all the inhibitors studied. It was found that the inhibitor molecule was adsorbed through more than one active centre and occupied more than one active site on the steel surface.
53 citations
TL;DR: A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1- C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method.
Abstract: A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C 1 C 7 ) compounds and was tested for their anti-inflammatory activity determined by rat-pawoedema method. All the synthesis compounds have been characterized by 1 HNMR, IR and Mass spectral data. The compounds were purified by column chromatography. All synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for antiinflammatory activity. The entire compound gives good response for the anti-inflammatory activity: [3-Chloro-N-[5-(3-Chloro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (C 4 ), and [4-Nitro-N-[5-(4-Nitro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (C 7 ). For this activity, indometacin was used as a standard drug and compared to new synthesized drugs. Some new synthesized drugs have shown better activities for the anti-inflammation.
45 citations
TL;DR: The mechanism of the classical color reaction between chromate and carbazide has been studied in solution from various physico-chcmical points of view as discussed by the authors, which leads to the conclusion that tlie chromate-carbazidc reaction is a composite one involving preliminary oxidation followed subsequently by complex formation.
Abstract: The mechanism of the classical colour reaction between chromate and carbazide has been studied in solution from various physicochcmical points of view. It has been established from spectral identity that the same red-violet compound is produced in the 3 different reaction systems, chromate-carbazidc, chromate-carbazone and chromous-carbazonc. This leads to the conclusion that tlie chromate-carbazidc reaction is a composite one involving preliminary oxidation followed subsequently by complex formation. Moreover, the actual constituents involved in the reaction have been identified as Cr +2 on the one hand and carbazone on the other, giving rise to an intensely coloured inner complex compound. The inner complex nature of the coloured product was gauged independently from migration studies and from extraction of the coloured compound by non-polar solvents.
41 citations