Carbohydrazide

About: Carbohydrazide is a research topic. Over the lifetime, 888 publications have been published within this topic receiving 8140 citations. The topic is also known as: diaminourea & carbonodihydrazide.

Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives

Abstract: Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities.

Combustion synthesis of fine-particle metal aluminates

Abstract: Fine-particle metal aluminates,$MAl_20_4$ where $M = Mg$, $Ca$, $Sr$, $Ba$, $Mn$, $Co$, $Ni$, $Cu$ and $Zn$ as well as $3CaO . Al_2O_3$ $(C_3A)$, $CaAl_{12}O_{19}$ $(CA_6)$ and $MgCeAl_{11}O_{19}$ have been prepared by the combustion of mixtures of the respective metal nitrates (oxidizers) and urea or carbohydrazide (fuels) at 500 or $350^0c$ respectively, over a time of 5min. The solid combustion products were identified by their characteristic X-ray powder diffraction patterns. The fine-particle nature of these metal aluminates was investigated using SEM, TEM, particle size analysis and surface area measurements. The surface areas of the as-prepared metal aluminates using carbohydrazide fuel were higher (45 to 85 $m^2g^{-1}$) compared with urea (1 to 20 $m^2g^{-1}$).

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells.

Abstract: A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated The results showed that all compounds had almost inhibitory effects on the growth of A549 cells The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with Log P values in the range of 412–680 had inhibitory effects on the growth of A549 cells, and among of them the hydrazone derived from salicylaldehyde had much more inhibitory effects

Synthesis and properties of Eu2+ activated blue phosphors

Abstract: Blue phosphors Eu2+ activated BaMgAl10O17, BaMg2Al16O27, xBaO·6Al2O3 where x = 0.64−1.8 and LaMgAl11O19 have been prepared by the combustion of corresponding metal nitrates (oxidizer) and carbohydrazide (CH)/diformyl hydrazine (DFH)/urea (fuel) redox mixture at 400 500° C within 5 min. The phosphors were characterized by exposure to UV light, powder XRD, fluorescence and electron paramagnetic resonance spectroscopy. The phosphors showed a characteristic emission band in the region 435–462 nm when they were excited at 254 nm. With an increase in barium content in xBaO·6Al2O3 (x = 0.64−1.8) the emission band showed a red shift. Addition of Mn2+ in Eu2+ doped barium hexa aluminates and Eu2+ doped LaMgAl11O19 resulted in strong green emission at 515 nm. The fine particle nature of combustion derived phosphors has been studied by powder density (55–82% of theoretical value), particle size (5.7–9.5 μm) and BET surface area (5–22 m2 g−1) measurements.

Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building.

Abstract: Tuberculosis (TB) remains among the world's great public health challenges. Worldwide resurgence of TB is due to two major problems: the AIDS epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant (MDR) TB. Thus, there is an urgent need for anti-TB drugs with enhanced activity against MDR strains. In recent years, Schiff bases of 1H-indole-2,3-diones are reported to exhibit anti-TB activity. On the other hand, several quinolone antibacterial agents have been examined as inhibitors of TB, as well as other mycobacterial infections. Accordingly, the current work involved design and synthesis of Schiff bases of nalidixic acid carbohydrazide and isatin derivatives (5,6a-f and 7,8a-c). Structures of the synthesized derivatives were confirmed on the bases of spectral methods of analyses. Anti-TB activity of the synthesized derivatives was investigated against four Mycobacterium strains: Mycobacterium intercellulari, Mycobacterium xenopi, Mycobacterium cheleneo and Mycobacterium smegmatis. Modest anti-TB activity was observed within the investigated compounds, however, compound 5f revealed potent anti-TB activity with MIC 0.625 microg/ml, which is 20 times greater than the reference drug isoniazid, INH, (MIC = 12.5 microg/ml). A hypothetical pharmacophore model was built using Molecular Operating Environment (MOE) program and 10 compounds structurally related to the synthesized ones with reported anti-TB activity. The Pharmacophoric model built revealed the necessity of the following pharmacophoric features for anti-TB activity: aromatic center, hydrogen bond acceptor/metal ligator center, hydrogen bond donor center and aromatic center/hydrophobic area. Theses features were consistent with the found anti-TB activity of the tested compounds.