Topic
Carboxylic acid
About: Carboxylic acid is a research topic. Over the lifetime, 48544 publications have been published within this topic receiving 605696 citations.
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TL;DR: The hexameric n-butyloxotin benzoate, [n-BuSn(O)O2CC6H4NO2.2]6] and the dimeric methyloxotin cyclohexanoate, this article, were prepared by condensing the stannoic acid with the respective carboxylic acid.
Abstract: The hexameric n-butyloxotin benzoate, [n-BuSn(O)O2CC6H4NO2.2]6.3C6H6, 1, and the dimeric methyloxotin cyclohexanoate, [(MeSn(O)O2CC6H11)2MeSn(O2CC6H11)3]2, 4, were prepared by condensing the stannoic acid with the respective carboxylic acid. Reaction of n-butyltin. trichloride with the silver salt of the respective carboxylic acid gave the dimeric n-butyloxotin carboxylate compositions, [(n-BuSn(O)O2CR)2-n-BuSn(O2CR)3]2, 2 (R = Ph) and 3 (R = Me). These represent new substances and, as found by X-ray analysis, form a new structural class of organotin compounds for 2-4 having “unfolded drum” or “ladder” structures. The hexamer composition 1 exists in “drum” form. 119Sn NMR data show that the drum and ladder structures interconvert reversibly. 1 crystallizes in the rhombohedral/space group R3 with a H = 15.283 (4) A, cH, = 34.683 (9) A, and Z = 3. 2 crystallizes in the triclinic space group P1 with a = 13.657 (6) A, b = 14.104 (2) A, c = 14.559 (4) A, a = 99.14 (2)°, β = 111.73 (3)°, γ = 101.57 (3)...
124 citations
TL;DR: In this article, the stability of a hydrogen-bonded complex built through inter-molecular hydrogen bonding between carboxylic acid and pyridine fragments has been examined using infrared spectroscopy.
Abstract: The stability of a hydrogen-bonded complex built through inter-molecular hydrogen bonding between carboxylic acid and pyridine fragments has been examined using infrared spectroscopy. Infrared spectra as a function of temperature have been recorded for the 1:1 complex of 4-hexyloxybenzoic acid and trans-4-propoxy-4′-stilbazole from the crystalline state to the isotropic state. A dependence of the stability of the hydrogen bond on molecular orientation is observed clearly in the infrared spectra. The spectra also suggest that the hydrogen bond is an unionized type with a double minimum potential energy.
124 citations
TL;DR: An overview is presented of chromatographic methods currently in use to determine sugars, carboxylic acids and amino acids in foods: high-performance liquid chromatography, gas chromatography and capillary electrophoresis.
124 citations
Patent•
Alza1
TL;DR: In this paper, a system for the controlled continuous administration of an active agent to an environment of use is described, which comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough.
Abstract: A device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic acid) having one ionizable carboxylic hydrogen for each 8 to 12 carbon atoms, which material erodes at a controlled and continuous rate over a prolonged period of time in response to the environment by a process of carboxylic hydrogen ionization, thereby releasing the dispersed agent at a controlled rate over a prolonged period of time.
123 citations
TL;DR: P palladium-catalyzed carbonylation of aryl, alkenyl, and allyl halides with phenyl formate with a variety of heteroaromatic bromides can be converted to the corresponding phenyl esters in high yields.
123 citations