Topic
Carboxylic acid
About: Carboxylic acid is a research topic. Over the lifetime, 48544 publications have been published within this topic receiving 605696 citations.
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TL;DR: The binding affinity and selectivity of ethylene glycol dimethacrylate and methacrylic acid imprinted copolymers were evaluated chromatographically and specific binding was found for adenine, cytosine, and guanosine derivatives.
Abstract: Molecular imprinting technology was used to create polymeric receptors for the DNA and RNA bases. The binding affinity and selectivity of ethylene glycol dimethacrylate (EGDMA) methacrylic acid (MAA) imprinted copolymers were evaluated chromatographically. Specific binding was found for adenine, cytosine, and guanosine derivatives. These bases contain a 2-aminopyridine substructure previously found important for the binding and specificity of polymers imprinted with 9-ethyladenine. Thymine and uracil derivatives, which do not contain the 2-aminopyridine substructure, exhibited little specific binding to the imprinted polymers. The magnitude of the binding affinity for each of the nucleoside derivatives to its own imprinted polymer follows the order A > G > C > T, U. This differs from the order of binding between butyric acid and the RNA base derivatives in solution (G > C > A > U: Lancelot, G. J. Am. Chem. Soc. 1977, 99, 7037) or between control polymers that contain randomly distributed carboxylic acid ...
97 citations
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01 Mar 2003-Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment
TL;DR: A direct generic ELISA for both the quinolones and fluoroquinolones has been developed that uses the cross-reactivity of an antibody raised against norfloxacin linked to ovalbumin via a secondary amine group on the piperazinyl moiety to detect nine different drugs in these classes of antimicrobial compounds.
Abstract: Several quinolone and fluoroquinolone haptens have been used to raise polyclonal antibodies exhibiting both specific and generic properties for these classes of antimicrobial compounds. The antisera have been assessed in rapid enzyme immunoassays (ELISAs) designed to exploit the specificities obtained. A direct generic ELISA for both the quinolones and fluoroquinolones has been developed that uses the cross-reactivity of an antibody raised against norfloxacin (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid) linked to ovalbumin via a secondary amine group on the piperazinyl moiety to detect nine different drugs in these classes. Specific ELISAs to ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid), enrofloxacin (1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid), flumequin (9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid) and nalidixic acid (1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid) have also been developed with a high degree of specificity to the individual compounds. The assays measure drug residues in bovine milk and ovine kidney with an interassay relative standard deviation (s(r)) of 10.5% or less and intra-assay s(r) of 11.2% or less. Sensitivity is less than 4 microg x kg(-1) for both the generic and specific assays for all but one of the compounds tested. (Pipemidic acid (8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid) is detectable at 6 microg x kg(-1) in kidney.)
96 citations
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TL;DR: In this article, the chemistry of formic, acetic and oxalic acids was studied at four sites representing the urban and rural conditions in Beijing from March 2002 to October 2003.
96 citations
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TL;DR: A submitted manuscript is the author's version of the article upon submission and before peer-review as mentioned in this paper, and the final published version features the final layout of the paper including the volume, issue and page numbers.
Abstract: • A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
96 citations
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TL;DR: This communication describes the partial purification and some properties of a pyridine nucleotide requiring enzyme from ox liver which oxidizes Ai-pyrroline-5-carboxylic acid to glutamic acid.
96 citations