Cardiac cycle

About: Cardiac cycle is a research topic. Over the lifetime, 3290 publications have been published within this topic receiving 96159 citations.

Alterations in pulse wave propagation reflect the degree of outflow tract banding in HH18 chicken embryos

Abstract: Hemodynamic conditions play a critical role in embryonic cardiovascular development, and altered blood flow leads to congenital heart defects. Chicken embryos are frequently used as models of cardiac development, with abnormal blood flow achieved through surgical interventions such as outflow tract (OFT) banding, in which a suture is tightened around the heart OFT to restrict blood flow. Banding in embryos increases blood pressure and alters blood flow dynamics, leading to cardiac malformations similar to those seen in human congenital heart disease. In studying these hemodynamic changes, synchronization of data to the cardiac cycle is challenging, and alterations in the timing of cardiovascular events after interventions are frequently lost. To overcome this difficulty, we used ECG signals from chicken embryos (Hamburger-Hamilton stage 18, ∼3 days of incubation) to synchronize blood pressure measurements and optical coherence tomography images. Our results revealed that, after 2 h of banding, blood pressure and pulse wave propagation strongly depend on band tightness. In particular, while pulse transit time in the heart OFT of control embryos is ∼10% of the cardiac cycle, after banding (35% to 50% band tightness) it becomes negligible, indicating a faster OFT pulse wave velocity. Pulse wave propagation in the circulation is likewise affected; however, pulse transit time between the ventricle and dorsal aorta (at the level of the heart) is unchanged, suggesting an overall preservation of cardiovascular function. Changes in cardiac pressure wave propagation are likely contributing to the extent of cardiac malformations observed in banded hearts.

MR angiography with a cardiac-phase--specific acquisition window.

Abstract: A method for cardiac-phase-specific magnetic resonance (MR) angiography is presented. An electronics module permits incrementing of phase-encoding gradients and storage of incoming data only during a chosen portion of the cardiac cycle. Suppression of stationary material is maintained by delivering radio-frequency pulses at constant TR throughout the cycle. Imaging of a pulsatile flow phantom demonstrates that acquiring data only during systole substantially increases the signal intensity of flowing material. In addition, phase-encoding ghost artifacts are eliminated from the neighborhood of the vessel. Image acquisition time is minimized by acquiring only the low-frequency phase-encoding lines in the cardiac-phase-specific mode. In healthy volunteers, greatly improved MR angiograms of the lower extremities are obtained. Fat saturation and magnetization transfer further enhance vessel/background contrast. Acquiring data only during systole ensures rapid inflow for all phase-encoding lines, permitting a near-longitudinal section orientation without in-plane saturation. This substantially reduces total acquisition time relative to axial acquisition.

Value of left atrial strain: a highly promising field of investigation

Abstract: The principal role of the left atrium (LA) is to modulate left ventricular filling and cardiovascular performance by functioning as (i) a reservoir for pulmonary venous return during ventricular systole, (ii) a conduit for pulmonary venous return during early ventricular diastole, and (iii) a booster pump that augments ventricular filling during late ventricular diastole. The interplay between these atrial functions and ventricular performance throughout the cardiac cycle is crucial in many pathophysiological conditions.1,2 However, in clinical practice, we do not really assess all of the components of LA function. In fact, quantification of LA function remains challenging. Calculating ejection fraction or atrial ejection force has occasionally been proposed as methods for quantifying LA function, but they are neither routinely used nor recommended in the literature.3 Standard recommendations in the literature propose using LA volume calculated from trans-thoracic 2D echocardiography orthogonal views.3,4 LA size correlates with both LA and left ventricular (LV) function and is a strong predictor of cardiovascular morbidity and death.5 The antero-posterior diameter, calculated with M-mode or 2D echocardiography, is no longer considered to adequately represent the true LA size. For these reasons, the ASE/EACVI joined paper3 …

Hemodynamic features of prolapsing and nonprolapsing left atrial myxoma.

Abstract: In the course of the evaluation of five patients with left atrial myxoma, it was noted that the movement of the myxoma was related to specific changes in left atrial hemodynamics. Prolapsing tumors, Type I, move from the left ventricle to the left atrium in early systole and from the left atrium to the left ventricle in early diastole, thereby causing prominent c and v waves accompanied by a rapid y descent. Nonprolapsing tumors, Type II, remain in the left atrium during the entire cardiac cycle, impeding flow across the mitral valve. In these latter cases, the y descent is slow and indistinguishable from that caused by mitral valvular stenosis. The cineangiocardiograms and echocardiograms corroborate these two types of hemodynamic observations. The particular value of direct echocardiographic examination of the left atrium prior to cardiac catheterization was evident in two of the three patients with nonprolapsing tumors. Since the hemodynamic pattern of nonprolapsing left atrial myxoma resembles that of mitral valvular stenosis, it is stressed that echocardiography should have an important place in precatheterization assessment of patients with mitral valve disease. If left atrial myxoma is suspected clinically or on the basis of echocardiographic findings, regardless of the pressure curve contours, transseptal cardiac catheterization should be avoided and the left atrium visualized by pulmonary angiography levophase.

Tidal variation of pulmonary blood flow and blood volume in piglets during mechanical ventilation during hyper-, normo- and hypovolaemia

Abstract: Effects of changes in blood volume on changes in pulmonary blood flow and pulmonary blood volume during the ventilatory cycle during mechanical ventilation with a positive end-expiratory pressure of 2 cm H2O were determined in six pentobarbital anaesthetized, curarized pigs weighing about 10 kg. Haemodynamic variables were analysed for each cardiac cycle in eight ventilatory cycles in four consecutive series under hyper-, normo- and hypovolaemic conditions. Cardiac output was highest in hypervolaemia. Compared with normo- and hypovolaemia, it decreased less during inflation, due to a smaller rise in central venous pressure and presumably a larger filling state of the venous system. The smaller decrease in right ventricular output in hypervolaemia coincided with a larger fall in transmural central venous pressure (right ventricular filling pressure), due to right ventricular action at a higher, less steep part of its function curve. The difference between right ventricular-output (electromagnetic flow measurement) and left ventricular-output (pulse contour) indicated changes in pulmonary blood volume. In hypervolaemia less blood shifted from the pulmonary circulation into the systemic system during inflation than in normo- and hypovolaemia. This difference can be explained by two mechanisms namely, the smaller fall in input into the pulmonary vascular beds and a smaller pulmonary vascular volume decrease as a result of transmural pressure fall at a steeper part of the pressure-volume curve.