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Carroll rearrangement
About: Carroll rearrangement is a research topic. Over the lifetime, 1483 publications have been published within this topic receiving 23513 citations.
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136 citations
TL;DR: Transition metal catalyzed decarboxylation of β-keto acids and esters provides a convenient route for the regiospecific generation of enolates under neutral conditions as mentioned in this paper.
136 citations
TL;DR: The Smiles rearrangement is the intramolecularucleophilic aromatic substitution reaction incorporating a heteroatom as the nucleophilic component and an activated electrophilic arene and one particular variation--the Truce-Smiles rearranged--utilises a carbon-based nucleophile and an electrophobic arene which does not require additional activation.
Abstract: The Smiles rearrangement is the intramolecular nucleophilic aromatic substitution reaction incorporating a heteroatom as the nucleophilic component and an activated electrophilic arene. One particular variation—the Truce–Smiles rearrangement—utilises a carbon-based nucleophile and an electrophilic arene which does not require additional activation. Such a variation generates a new carbon–carbon bond and the synthetic utility of this relatively under-utilised rearrangement is discussed in this tutorial review.
124 citations