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Topic

Cartilage

About: Cartilage is a research topic. Over the lifetime, 27192 publications have been published within this topic receiving 1072352 citations. The topic is also known as: cartilaginous part & cartilaginous part of bone.


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Journal ArticleDOI
TL;DR: Research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view is reviews from a biodegradable and bioresorbable perspective.

4,914 citations

Journal ArticleDOI
01 Aug 1982-Cell
TL;DR: Using SDS-polyacrylamide gel electrophoresis of intact collagen chains and two-dimensional cyanogen bromide peptide mapping, this work demonstrated a complete return to the differentiated collagen phenotype and demonstrates a reversible system for the study of gene expression.

2,296 citations

Journal ArticleDOI
TL;DR: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo -arthritic process.
Abstract: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo-arthritic process. The DNA and hexosamine concentrations were determined as indicators of cell density and polysaccharide con

2,168 citations

Journal ArticleDOI
TL;DR: It is shown that VEGF-mediated capillary invasion is an essential signal that regulates growth plate morphogenesis and triggers cartilage remodeling and VEGf is anessential coordinator of chondrocyte death, chondROclast function, extracellular matrix remodeling, angiogenesis and bone formation in the growth plate.
Abstract: Hypertrophic chondrocytes in the epiphyseal growth plate express the angiogenic protein vascular endothelial growth factor (VEGF). To determine the role of VEGF in endochondral bone formation, we inactivated this factor through the systemic administration of a soluble receptor chimeric protein (Flt-(1-3)-IgG) to 24-day-old mice. Blood vessel invasion was almost completely suppressed, concomitant with impaired trabecular bone formation and expansion of hypertrophic chondrocyte zone. Recruitment and/or differentiation of chondroclasts, which express gelatinase B/matrix metalloproteinase-9, and resorption of terminal chondrocytes decreased. Although proliferation, differentiation and maturation of chondrocytes were apparently normal, resorption was inhibited. Cessation of the anti-VEGF treatment was followed by capillary invasion, restoration of bone growth, resorption of the hypertrophic cartilage and normalization of the growth plate architecture. These findings indicate that VEGF-mediated capillary invasion is an essential signal that regulates growth plate morphogenesis and triggers cartilage remodeling. Thus, VEGF is an essential coordinator of chondrocyte death, chondroclast function, extracellular matrix remodeling, angiogenesis and bone formation in the growth plate.

2,003 citations

Journal ArticleDOI
TL;DR: Some biomaterials, which have been suggested to promote chondrogenesis and to have potentials for tissue engineering of articular cartilage, are reviewed and a new biomaterial, a chitosan-based polysaccharide hydrogel, is introduced and discussed in terms of the biocompatibility with chondrocytes.

1,868 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20241
20231,365
20222,833
20211,118
20201,098
20191,027