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Showing papers on "Catechol-O-methyl transferase published in 1972"


Journal ArticleDOI
TL;DR: There is a significant correlation between blood COMT activity and SAMe concentration, which suggests that some schizophrenics may methylate biogenic amines more actively than others.
Abstract: The authors examined the hypothesis of disordered transmethylation in schizophrenia by comparing S-adenosylmethionine (SAMe) concentration and cathechol-O-methyltransferase (COMT) activities in venous blood of schizophrenic and nonschizophrenic patients. While they did not find a difference in blood SAMe concentration between the groups, they did find a significant correlation between blood COMT activity and SAMe concentration. This suggests that some schizophrenics may methylate biogenic amines more actively than others.

59 citations


Journal ArticleDOI
TL;DR: Dopamine concentration in the left striatum was reduced about 70% compared with the right striatum after successful lesions in the substantia nigra and 5-Hydroxytryptamine concentration was measured in the forebrain after the different lesions.

42 citations



Journal ArticleDOI
TL;DR: Catechol- O -methyltransferase (COMT) enzyme activity in the Sprague-Dawley male rat pineal gland shows a 24-hour rhythm with the highest levels during the light period and the lowest during darkness, and the rhythmic variation of COMT is abolished when animals are kept in continuous light.

13 citations


Journal ArticleDOI
TL;DR: In the brain, pyrogallol led to marked increases of unmetabolized 3 H-L-dopa and to greater accumulations of labelled catecholamines and deaminated catechols, but to decreases of O-methylated metabolites.

11 citations