Topic
Catechol-O-methyl transferase
About: Catechol-O-methyl transferase is a research topic. Over the lifetime, 1646 publications have been published within this topic receiving 87360 citations.
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TL;DR: Positron emission tomographic studies in baboon and studies in mice provide the first example of a positron emitter labeled radiotracer for COMT, and initial encouraging evidence that [18F]Ro41-0960 may be used to examine COMT in peripheral organs in vivo.
21 citations
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TL;DR: This is the first report of any population with lower RBC COMT activity than a Caucasian population and a wide range of RBCCOMT activities was found in the entire population examined.
Abstract: Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol hormones, neurotransmitters and certain drugs. It is subject to genetic polymorphism and ethnic differences. High red blood cell (RBC) COMT activity has been correlated with a poor response to levodopa treatment in Parkinson's disease. RBC COMT was determined in a Norwegian population (n=213) of whom 115 were Saami (Lapps).
21 citations
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TL;DR: The specific COMT inhibitors, nitecapone and OR-611, effectively inhibited in vitro the human intestinal COMT activity with Nanomolar concentrations caused 50% inhibition with both DBA and L-DOPA as substrate.
21 citations
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TL;DR: The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
Abstract: The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
20 citations
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TL;DR: The interaction of COMT Val(158)Met and SLC6A4 5-HTTLPR adds to the understanding of individual differences in emotion processing.
Abstract: There have been several reports on the association between the Val158Met genetic polymorphism of the catechol-O-methyltransferase gene (COMT), as well as the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4), and fronto-limbic region volumes, which have been suggested to underlie individual differences in emotion processing or susceptibility to emotional disorders. However, findings have been somewhat inconsistent. This study used diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) whole-brain voxel-based morphometry (VBM) to study the genetic effects of COMT Val158Met and SLC6A4 5-HTTLPR, as well as their interaction, on the regional gray matter volumes of a sample of 91 healthy volunteers. An interaction of COMT Val158Met x SLC6A4 5-HTTLPR genotypes with gray matter volume was found in bilateral parahippocampal gyrus, amygdala, hippocampus, vermis of cerebellum and right putamen / insula. In particular, the gray matter volume in these regions was smaller in individuals who were both COMT-Met and 5-HTTLPR-S carriers, or both COMT-Val and 5-HTTLPR-L homozygotes, as compared to individuals with intermediate combinations of alleles. The interaction of COMT Val158Met and SLC6A4 5-HTTLPR adds to the understanding of individual differences in emotion processing.
20 citations