Topic
Catechol-O-methyl transferase
About: Catechol-O-methyl transferase is a research topic. Over the lifetime, 1646 publications have been published within this topic receiving 87360 citations.
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TL;DR: The theory that COMTL allele was related with increased tonic dopamine activity and cognitive ‘stability’, which may induce cognitive inflexibility in schizophrenia, is supported.
Abstract: We assessed catechol-O-methyltransferase (COMT) polymorphism in 132 first-onset schizophrenic patients and 80 healthy controls. The relationship between COMT polymorphism and cognitive function, aggression and psychiatric symptoms was tested in the schizophrenic group. COMT L carrier had higher digit span score and lower similarity score than COMT H homozygote. COMT L carrier had higher attention and delusion scores and lower inappropriate affect scores than COMT H homozygote. Attention and delusion scores of COMT L allele were higher than COMT H allele. COMT L group had higher aggression than COMT H homozygote. Our results support the theory that COMT L allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia.
64 citations
TL;DR: Contrary to the observed association between WCST performance and the Val108/158Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.
Abstract: Background
An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD) are mediated by prefrontal dopamine (DA) mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children
64 citations
TL;DR: The result indicates that the decrease in tissue levels of S-Adenosylmethionine in organs of senescent rats is due to the increased utilization rather than the decreased synthesis of this methyl donor compound.
Abstract: The tissue levels of S-Adenosylmethionine (SAMe) in 30-mo.-old rats were measured, and a remarkable decrease was observed compared to adult rats. The synthesis of SAMe by the methionine-activating enzyme and its utilization by COMT were investigated in different tissues. The activity of the synthesizing enzyme was unchanged in the liver and brain of adult and senescent rats, while COMT activity appeared to be higher in the aging rats. Thus, the result indicates that the decrease of same in these organs of senescent rats is due to the increased utilization rather than the decreased synthesis of this methyl donor compound.
63 citations
TL;DR: The results illustrate that epistasis can be functionally multi-directional and non-linear and that a putatively beneficial allele in one epistastic context is a relatively deleterious one in another.
Abstract: Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans
63 citations
TL;DR: Tolcapone could be potentially useful in the treatment of conditions with deficient sensorimotor gating and working memory such as schizophrenia and prodromal states but only in a genotype-specific manner.
63 citations