Topic
CATS
About: CATS is a research topic. Over the lifetime, 5814 publications have been published within this topic receiving 138175 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus, and appears to be antigenically distinct from human immunodeficiency virus.
Abstract: A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new virus, whereas 10 of 25 cats with signs of ill health were seropositive for the virus. Tentatively designated feline T-lymphotropic lentivirus, this new feline retrovirus appears to be antigenically distinct from human immunodeficiency virus. There is no evidence for cat-to-human transmission of the agent. Kittens experimentally infected by way of blood or plasma from naturally infected animals developed generalized lymphadenopathy several weeks later, became transiently febrile and leukopenic, and continued to show a generalized lymphadenopathy 5 months after infection.
1,028 citations
TL;DR: The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.
Abstract: Cell proliferation in the brains of rats and cats was investigated autoradiographically Two young adult rats were injected intraperitoneally with 2 mc of thymidine-H3 and killed after a two weeks' exchange period Two adult cats were injected intraventricularly with 05 mc of thymidine-H3 and killed one week later Labeling of cell nuclei in the brain, presumed to reflect DNA turnover and cellular proliferation, was investigated In the rats, some neuroglia cells were found labeled in all parts of the brain, suggesting a low rate of glial proliferation In addition, circumscribed small regions with numerous labeled neuroglia and microglia cells were seen in several brain regions, suggesting the occurrence of local glial proliferative reactions in these presumably normal brains A few apparently labeled neurons were seen in the neocortex, and a proliferative region of granule cells was identified in the dentate gyrus of the hippocampus In the cats labeling of glia cells was highest in the midline region, near the point of injection of the radiochemical, with a gradient of decreasing number of labeled cells both laterally and in the anteroposterior direction of the neuraxis Neurons with apparently labeled nuclei were observed in the midline cortex bilaterally in both animals These results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores
590 citations
TL;DR: It would seem highly desirable to be able to elucidate the role of the unique system of basket cells (B-cells) with dendritic receptors in the molecular layer (and possibly elsewhere) and efferent axons (B.e.) in the cerebellar afferent system.
Abstract: Efferent cortical activity from the cerebellum is carried by the Purkinje cells (P-cells, see Fig. 1) which are the final common path (P.e.) of two major synaptic organizations. One is a complex polysynaptic network of dendrites and stellate cells in the superficial molecular or plexiform layer to which apparently both cerebellar afferent systems contribute though its main supply is from the mossy fibres (Mo.a.) over the granular cells (Gr.c.). The other afferent system is the monosynaptic one over the climbing fibres (Cl.a.) to P-cell dendrites along which they climb. These are held to contribute also to the polysynaptic network (Estable, 1923; Scheibel & Scheibel, 1954) and many other complexities are encountered, but to a first approximation the physiologist has to be content with a general subdivision of cerebellar afferents into monoand polysynaptic ones along the lines suggested. His next concern will be with the two additional systems centered on the P-cells one of which consists of two types of recurrent collaterals (P.r.): Cajal's (1911, fig. 12) 'plexus sous-cellulaire' spreads among the cells below the P-cells and his 'plexus sus-cellulaire' traverses the molecular layer giving off branches on its way. Both types of recurrent collaterals do, however, end up on P-cells. Finally, it would seem highly desirable to be able to elucidate the role of the unique system of basket cells (B-cells) with dendritic receptors in the molecular layer (and possibly elsewhere) and efferent axons (B.e.) surrounding the P-cell itself as well as the non-medullated and part of the medullated portion of its efferent axon (for good illustrations, see Estable, 1923; also Retzlaff, 1954). This basket, the 'nid' or 'nest of Cajal' (1911, p. 23), is the other major
477 citations