Topic
Cell Fate Control
About: Cell Fate Control is a research topic. Over the lifetime, 70 publications have been published within this topic receiving 2859 citations.
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TL;DR: Recent advances into how the UPR integrates information about the intensity and duration of ER stress stimuli in order to control cell fate inform an evolving mechanistic understanding of a wide variety of human diseases, thus opening up the potential for new therapeutic modalities to treat these diverse diseases.
911 citations
TL;DR: Recent progress is covered establishing an emerging relationship between stem cell metabolism and cell fate control, which offers a potential target for controlling tissue homeostasis and regeneration in aging and disease.
571 citations
TL;DR: Understanding how pioneer factors initiate chromatin dynamics and how such can be blocked at heterochromatic sites provides insights into controlling cell fate transitions at will.
314 citations
TL;DR: An overview of the contexts in which pioneer factors function, how they can target silent genes, and their limitations at regions of heterochromatin is provided.
Abstract: Distinct combinations of transcription factors are necessary to elicit cell fate changes in embryonic development. Yet within each group of fate-changing transcription factors, a subset called ‘pioneer factors’ are dominant in their ability to engage silent, unmarked chromatin and initiate the recruitment of other factors, thereby imparting new function to regulatory DNA sequences. Recent studies have shown that pioneer factors are also crucial for cellular reprogramming and that they are implicated in the marked changes in gene regulatory networks that occur in various cancers. Here, we provide an overview of the contexts in which pioneer factors function, how they can target silent genes, and their limitations at regions of heterochromatin. Understanding how pioneer factors regulate gene expression greatly enhances our understanding of how specific developmental lineages are established as well as how cell fates can be manipulated.
241 citations
TL;DR: The need for continuous single-cell quantification to understand molecular cell fate control as well as organizational and technical solutions for long-term imaging and tracking of stem cells are discussed.
Abstract: Continuous long-term single-cell observation provides insight into the molecular control of cell fate. This is particularly important for rare and heterogeneous populations of cells, such as mammalian stem cells. The current lack of usable off-the-shelf hardware and software for such experiments makes their implementation technically challenging. Here I discuss the need for continuous single-cell quantification to understand molecular cell fate control as well as organizational and technical solutions for long-term imaging and tracking of stem cells.
179 citations