scispace - formally typeset
Search or ask a question
Topic

Cell growth

About: Cell growth is a research topic. Over the lifetime, 104237 publications have been published within this topic receiving 3751303 citations. The topic is also known as: GO:0016049 & cellular growth.


Papers
More filters
Journal ArticleDOI
TL;DR: T-bet is induced by IFN-γ and STAT1 signaling during T cell activation and mediates STAT1-dependent processes of TH1 development, including the induction of IL-12Rβ2.
Abstract: T helper type 1 (T(H)1) cell development involves interferon-gamma (IFN-gamma) signaling through signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) signaling through STAT4 activation. We examined here T-bet regulation and evaluated the actions of T-bet in STAT1- and STAT4-dependent T(H)1 development processes. We found that T-bet expression during T cell activation was strongly dependent on IFN-gamma signaling and STAT1 activation, but was independent of STAT4. Ectopic T-bet expression strongly increased IFN-gamma production in T(H)2 cells activated by PMA-ionomycin, but weakly increased IFN-gamma production in T(H)2 cells stimulated by IL-12 IL-18 or OVA peptide antigen-presenting cell stimulation. In contrast, IL-12 IL-18 induced IFN-gamma production remained STAT4-dependent despite ectopic T-bet expression. Ectopic T-bet expression selectively induced expression of IL-12Rbeta2, but not IL-18Ralpha, in wild-type and STAT1(-/-) T(H)2 cells, but did not extinguish expression of GATA-3 and T(H)2 cytokines. Finally, ectopic T-bet did not directly induce expression of endogenous T- bet independently of IFN-gamma or STAT1. Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2.

1,021 citations

Journal ArticleDOI
22 Aug 2003-Cell
TL;DR: A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals.

1,020 citations

Journal ArticleDOI
TL;DR: Altered in miRNA expression contribute to tumor growth and response to chemotherapy, and Aberrantly expressed miRNA or their targets will provide mechanistic insight and therapeutic targets for cholangiocarcinoma.

1,014 citations

Journal ArticleDOI
TL;DR: The results suggest that the reversible inactivation of PTEN by H2O2 might be important for the accumulation of 3′-phosphorylated phosphoinositides and that the uncontrolled generation of H 2O2 associated with certain pathological conditions might contribute to cell proliferation by inhibiting PTEN function.

981 citations

Journal ArticleDOI
TL;DR: Focal-adhesion kinase is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
Abstract: Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

979 citations


Network Information
Related Topics (5)
Cell culture
133.3K papers, 5.3M citations
97% related
Signal transduction
122.6K papers, 8.2M citations
95% related
Cellular differentiation
90.9K papers, 6M citations
93% related
Gene expression
113.3K papers, 5.5M citations
91% related
Transcription factor
82.8K papers, 5.4M citations
90% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20233,956
20226,245
20215,196
20206,247
20196,050
20185,767