Topic
Cell growth
About: Cell growth is a research topic. Over the lifetime, 104237 publications have been published within this topic receiving 3751303 citations. The topic is also known as: GO:0016049 & cellular growth.
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TL;DR: It is inferred that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth.
758 citations
757 citations
TL;DR: It is suggested that IGFBP-3 induces apoptosis through a novel pathway independent of either p53 or the IGF·IGF receptor-mediated cell survival pathway and that IGF BP-3 mediates TGF-β1 induced apoptosis in PC-3 cells.
754 citations
TL;DR: FGF, a polypeptide found in brain and pituitary, provokes the initiation of DNA synthesis by resting ST3 cells by stimulating DNA synthesis as effectively as serum when glucocorticoids are present.
Abstract: FGF, a polypeptide found in brain and pituitary, provokes the initiation of DNA synthesis by resting ST3 cells. When glucocorticoids are present FGF stimulates DNA synthesis as effectively as serum.
752 citations
TL;DR: Evidence is provided that there may be a direct link between inhibition of intestinal cancer growth and selective inhibition of the COX-2 pathway.
Abstract: A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in persons taking aspirin or other nonsteroidal antiinflammatory drugs on a regular basis. One property shared by all of these drugs is their ability to inhibit COX, a key enzyme in the conversion of arachidonic acid to prostaglandins. Two isoforms of COX have been characterized, COX-1 and COX-2. COX-2 is expressed at high levels in intestinal tumors in humans and rodents. In this study, we selected two transformed human colon cancer cell lines for studies on the role of COX-2 in intestinal tumorigenesis. We evaluated HCA-7 cells which express high levels of COX-2 protein constitutively and HCT-116 cells which lack COX-2 protein. Treatment of nude mice implanted with HCA-7 cells with a selective COX-2 inhibitor (SC-58125), reduced tumor formation by 85-90%. SC-58125 also inhibited colony formation of cultured HCA-7 cells. Conversely, SC-58125 had no effect on HCT-116 implants in nude mice or colony formation in culture. Here we provide evidence that there may be a direct link between inhibition of intestinal cancer growth and selective inhibition of the COX-2 pathway.
751 citations