About: Cellular compartment is a(n) research topic. Over the lifetime, 1082 publication(s) have been published within this topic receiving 53794 citation(s). The topic is also known as: cell compartmentation.
Papers published on a yearly basis
23 Aug 1988-Biochemistry
TL;DR: Lipid biochemistry has remained a fairly esoteric branch of molecular cell biology, but this situation is now gradually changing with the discovery of phosphoinositide involvement in signal transduction.
Abstract: One of the challenges of contemporary cell biology is to unravel how the molecular composition of the different cellular compartments is generated and maintained during the cell cycle. In animal cells most of the efforts have been directed toward the study of how newly synthesized proteins are transported to their correct cellular destinations, whereas the lipids, which make up the framework of the membranes in the cell, have been given much less attention. Lipid biochemistry has remained a fairly esoteric branch of molecular cell biology. This situation is now gradually changing with the discovery of phosphoinositide involvement in signal transduction (Ber- ridge,
TL;DR: A model is proposed whereby three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network, which corresponds to a tubular reticulum on the trans side of the Golgi stack.
Abstract: The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).
TL;DR: The need to characterize individual TLR at the very beginning of signal initiation in order to understand their diverse biological functions is stressed.
Abstract: Recognition by innate immune cells of the pathogen associated molecular patterns (PAMP) lipopolysaccharide (LPS) from Gram-negative bacteria and bacterial CpG-DNA depends on Toll-like receptor4 (TLR4) and TLR9, respectively. To define differences in the response to these distinct PAMP we compared a key intracellular event, namely recruitment of myeloid differentiation marker 88 (MyD88) to the respective PAMP-initiated TLR signaling. Using MyD88-GFP fusion protein expressing macrophages we demonstrate that LPS and CpG-DNA trigger signaling from two different cellular locations: theformer at the cell membrane and the latter at the lysosomal compartment. While LPS does not require endocytosis to functionally associate with the membrane expressed TLR4/MD2 complex, internalization and endosomal maturation is conditional for CpG-DNA to activate TLR9. In support of these data TLR9 is not localized at the cell surface, but intracellularily. These data stress the need to characterize individual TLR at the very beginning of signal initiation in order to understand their diverse biological functions.
TL;DR: This review explores the possible involvement of different thermosensors in the plant response to warming and heat stress and the relationship between the different pathways and their hierarchical order is unclear.
Abstract: In plants, the heat stress response (HSR) is highly conserved and involves multiple pathways, regulatory networks and cellular compartments. At least four putative sensors have recently been proposed to trigger the HSR. They include a plasma membrane channel that initiates an inward calcium flux, a histone sensor in the nucleus, and two unfolded protein sensors in the endoplasmic reticulum and the cytosol. Each of these putative sensors is thought to activate a similar set of HSR genes leading to enhanced thermotolerance, but the relationship between the different pathways and their hierarchical order is unclear. In this review, we explore the possible involvement of different thermosensors in the plant response to warming and heat stress.
25 Nov 1955-Journal of Cell Biology
TL;DR: Cells of onion and garlic root tips were examined under the electron and phase contrast microscopes after fixation in KMnO4 to focus on the distribution and behavior of the endoplasmic reticulum (ER) during the several phases of mitosis.
Abstract: A survey of a large number of different cell types has indicated the presence of a network of membrane-bound cavities (the endoplasmic reticulum) in the cytoplasm of all cell types examined, with the exception of the mature erythrocyte. In its simplest form, encountered in seminal epithelia and in leucocytes, the reticulum consists mainly of interconnected strings of vesicles and appears to be randomly disposed in three dimensions. Local differentiations occur within the endoplasmic reticulum of all the cell types studied. The membrane limiting the cavities of the endoplasmic reticulum appears to be continuous with the cell membrane and the nuclear membranes.
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