Topic
Cellular compartment
About: Cellular compartment is a research topic. Over the lifetime, 1082 publications have been published within this topic receiving 53794 citations. The topic is also known as: cell compartmentation.
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TL;DR: Impaired bioenergetics associated with short-term increases in O-GlcNAc levels could be due to impaired, LonP1-dependent, mitochondrial complex protein turnover, which is known to target complex IV subunits and PINK1, in addition to other mitochondrial proteins.
Abstract: The attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine and threonine residues of proteins in distinct cellular compartments is increasingly recognized as an important mechanism r...
17 citations
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TL;DR: It is shown that proteins inside intact mitochondria isolated from human cells can be structurally characterized by NMR (in-mitochondria NMR), and the folding and maturation state of two human proteins in the IMS, SOD1 and Mia40 are characterized.
17 citations
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TL;DR: It is reported that CaCl2 as well as cell wall stress-inducing agents stimulate ROS production and that ΔBCnoxB produces significantly less ROS than the wild type and ΔbcnoxA.
17 citations
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TL;DR: Septins are GTP-binding proteins, usually localized at the bud neck region and are involved in cytokinesis, and it is shown that during autophagy prevalent conditions, septins traffic between different cellular compartments such as Golgi, mitochondria, endosomes, plasma membrane, and vacuolar membranes.
Abstract: Autophagy is a vital conserved recycling process where eukaryotic cells remove unwanted proteins and organelles via lysosomal degradation and in turn, generate nutrients for the cells. The special feature of autophagy process is the formation of double-membrane vesicles called autophagosomes that engulf cellular cargo and deliver them to the vacuole or lysosomes for degradation. Inspite of more than 40 AuTophaGy (ATG) proteins and several organelles as known membrane source, autophagosome biogenesis is not entirely understood. We recently have discovered that septins contribute to autophagosome biogenesis. Septins are GTP-binding proteins, usually localized at the bud neck region and are involved in cytokinesis. Here, we show that during autophagy prevalent conditions, septins traffic between different cellular compartments such as Golgi, mitochondria, endosomes, plasma membrane, and vacuolar membranes.
17 citations
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TL;DR: It is demonstrated that during mitosis the activity of both enzymes is strong enough to react with the substrate applied during the staining procedure, and a characteristic pattern of membrane distribution in mitotic cells is observed.
16 citations