Topic
Cellular differentiation
About: Cellular differentiation is a research topic. Over the lifetime, 90966 publications have been published within this topic receiving 6099252 citations. The topic is also known as: Cellular differentiation & GO:0030154.
Papers published on a yearly basis
Papers
More filters
TL;DR: Transgenic plants overexpressing CLV3 are used to show that meristem cell accumulation and fate depends directly on the level ofCLV3 activity and that CLV 3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex.
Abstract: The fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA(CLV) genes encode the essential components of a negative, stem cell–restricting pathway. We used transgenic plants overexpressing CLV3 to show that meristem cell accumulation and fate depends directly on the level of CLV3 activity and that CLV3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex. We also demonstrate that the CLV pathway acts by repressing the activity of the transcription factor WUSCHEL, an element of the positive, stem cell–promoting pathway.
1,016 citations
TL;DR: The PLETHORA1 (PLT1) and PLT2 genes encoding AP2 class putative transcription factors, which are essential for QC specification and stem cell activity, are identified.
1,015 citations
TL;DR: The activation of NKT cells paradoxically can lead either to suppression or stimulation of immune responses, and one cannot predict which will occur, and many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation.
Abstract: Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an invariant T cell antigen receptor (TCR) alpha chain, and unusual requirements for thymic selection. They rapidly produce many cytokines after stimulation and thus influence diverse immune responses and pathogenic processes. Because of intensive research effort, we have learned much about factors promoting the development and survival of NKT cells, regulation of their cytokine production, and the means by which they influence dendritic cells and other cell types. Despite this progress, knowledge of the natural antigen(s) they recognize and their physiologic role remain incomplete. The activation of NKT cells paradoxically can lead either to suppression or stimulation of immune responses, and we cannot predict which will occur. Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation.
1,014 citations
TL;DR: These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.
1,013 citations
TL;DR: This review will discuss how DCs provide a rapidly in response to IL-2, which is produced by actiquantitative and qualitative framework for T cell antigen vated T cells and can act in autocrine and paracrine recognition.
1,013 citations