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Chain (algebraic topology)

About: Chain (algebraic topology) is a(n) research topic. Over the lifetime, 6235 publication(s) have been published within this topic receiving 68250 citation(s).

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Book
01 Jan 1969-

4,347 citations



Journal ArticleDOI
TL;DR: This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides.

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Abstract: During the past fifteen years we have been attacking the problem of the structure of proteins in several ways. One of these ways is the complete and accurate determination of the crystal structure of amino acids, peptides, and other simple substances related to proteins, in order that information about interatomic distances, bond angles, and other configurational parameters might be obtained that would permit the reliable prediction of reasonable configurations for the polypeptide chain. We have now used this information to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; we think that it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of synthetic polypeptides. A letter announcing their discovery was published last year [1]. The problem that we have set ourselves is that of finding all hydrogen-bonded structures for a single polypeptide chain, in which the residues are equivalent (except for the differences in the side chain R). An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations. For rotational angle 180° the helical configurations may degenerate to a simple chain with all of the principal atoms, C, C' (the carbonyl carbon), N, and O, in the same plane.

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2,334 citations


Book
31 Jan 1983-

901 citations



Network Information
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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20223
2021193
2020210
2019244
2018191
2017177

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Topic's top 5 most impactful authors

Rafael I. Nepomechie

9 papers, 170 citations

Jaroslaw Paturej

7 papers, 24 citations

Martin Dyer

7 papers, 263 citations

Franco Ferrari

6 papers, 13 citations

Pramod Kumar Mishra

6 papers, 43 citations