Topic
Character (mathematics)
About: Character (mathematics) is a research topic. Over the lifetime, 46723 publications have been published within this topic receiving 411412 citations.
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TL;DR: It is shown that exemplar fragment libraries underexploit the potential of 3D character in fragment-like chemical space and that drug-like molecules in the libraries examined are predominantly 2D in character.
Abstract: We describe a computational method, plane of best fit (PBF), to quantify and characterize the 3D character of molecules. This method is rapid and amenable to analysis of large diverse data sets. We compare PBF with alternative literature methods used to assess 3D character and apply the method to diverse data sets of fragment-like, drug-like, and natural product compound libraries. We show that exemplar fragment libraries underexploit the potential of 3D character in fragment-like chemical space and that drug-like molecules in the libraries examined are predominantly 2D in character.
82 citations
Book•
01 Jan 2011
82 citations
01 Jan 1994
82 citations
Patent•
04 Dec 1998TL;DR: In this article, a character set that associates character glyphs with particular data values is used to identify the unknown language of text represented by a series of data values in accordance with the character set.
Abstract: The present invention provides a facility for identifying the unknown language of text represented by a series of data values in accordance with a character set that associates character glyphs with particular data values. The facility first generates a characterization that characterizes the series of data values in terms of the occurrence of particular data values on the series of data values. For each of a plurality of languages, the facility then retrieves a model that models the language in terms of the statistical occurrence of particular data values in representative samples of text in that language. The facility then compares the retrieved models to the generated characterization of the series of data values, and identifies as the distinguished language the language whose model compares most favorably to the generated characterization of the series of data values.
82 citations
TL;DR: The initial results of a mouse experiment of similar design are described, in which acquired characters were ‘assimilated’ by the genotype.
Abstract: WADDINGTON1 has described selection experiments in Drosophila in which acquired characters were ‘assimilated’ by the genotype. This communication describes the initial results of a mouse experiment of similar design.
82 citations