Chemical binding

About: Chemical binding is a research topic. Over the lifetime, 1822 publications have been published within this topic receiving 52516 citations.

Incorporation of redox couples into p-chlorosulfonated polystyrene coated electrodes by chemical binding

Abstract: On peut incorporer dans des films de polystyrene chlorosulfone, formes sur les surfaces des electrodes de platine ou de carbone vitreux des couples redox, correspondant a des complexes polypyridyles de fer, de ruthenium et d'osmium, un complexe ammino de Ru et des complexes de Ni avec une porphyrine ou un autre macrocycle

Functionalization of nanoparticles in specific targeting and mechanism release

Abstract: The development of various nanotechnologies have provided a new field of research, which allows the manipulation of molecular components of matter and covers a vast array of nanodevices. The “smart” multifunctional nanostructures should work as customizable, targeted drug-delivery vehicles capable of carrying large doses of therapeutic agents into malignant cells. Some nanomedical approaches are based on the use of functionalized nanoparticles (NPs), not only to reduce toxicity and side effects of drugs but, also in potential the biological barriers crossing on, such as: the blood–brain barrier, different cellular compartments, including the nucleus. Currently, many materials are used for nanoparticle preparation, several of biological derivation, such as albumin, gelatin, phospholipids, etc.; others of chemical nature, such as various polymers, hydrogels, solid metals. Covalent and noncovalent chemical linking using different molecules have been reported for NPs surface functionalization, confer them specific properties, such as targeting ability. Based on the strategy chosen to control release (pH or redox or temperature sensitive NPs), different drugs are linked to NPs by adsorption, incorporation, or chemical binding. Use of smart nanocarriers can be a successful approach to overcome the limits of drug delivery.

New characteristic signatures from time‐dependent static light scattering during polymer depolymerization, with application to proteoglycan subunit degradation

Abstract: Models were developed for the time-dependent light scattering intensity for simply branched (“comb”) polymers undergoing one or more of three distinguishable degradation mechanisms: (a) stripping off the side chains, (b) randomly degrading off the side chains, and (c) randomly degrading the backbone. The model equations were applied to the analysis of different types of degradation of simply branched biopolymers—bovine nasal cartilage proteoglycan subunits (or “monomers”); NaOH stripped off the glycosaminoglycan (GAG) chains from the protein backbone [mechanism (a)], whereas hyaluronidase seemed to randomly cleave the GAG side chains [mechanism (b)], and HCl both stripped the GAG side chains and randomly cleaved the protein backbone [combined mechanisms (a) and (c)]. The reactions were followed with time-dependent multiangle, static light scattering. The time-resolved total scattering technique allowed degradation rate constants and percentage of material in the branched polymer backbone and side chains to be determined, in addition to the mechanisms involved. These new time-dependent light scattering profiles are added to the growing library of functions from which deductions can be made concerning polymer structure and associated degradation mechanisms and kinetics. These conclusions, drawn from time-dependent “batch” light scattering, are substantiated by preliminary size exclusion chromatography results and chemical binding assays for sulfated GAGs. © 1995 John Wiley & Sons, Inc.