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Chemical binding

About: Chemical binding is a research topic. Over the lifetime, 1822 publications have been published within this topic receiving 52516 citations.


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Patent
29 Apr 2015
TL;DR: In this paper, a method for generating multiple holes in graphene in a periodic way to create a graphene nanomesh with a patterned array of multiple holes, passivating an edge of each of the multiple holes of the graphene nanomeh to allow for functionalization of the graphite, and functionalizing the passivated edge of a single hole with a chemical compound that facilitates chemical binding of a receptor of a target molecule to the edge of one or more of the holes.
Abstract: A graphene nanomesh based charge sensor and method for producing a graphene nanomesh based charge sensor. The method includes generating multiple holes in graphene in a periodic way to create a graphene nanomesh with a patterned array of multiple holes, passivating an edge of each of the multiple holes of the graphene nanomesh to allow for functionalization of the graphene nanomesh, and functionalizing the passivated edge of each of the multiple holes of the graphene nanomesh with a chemical compound that facilitates chemical binding of a receptor of a target molecule to the edge of one or more of the multiple holes, allowing the target molecule to bind to the receptor, causing a charge to be transferred to the graphene nanomesh to produce a graphene nanomesh based charge sensor for the target molecule.

12 citations

Journal ArticleDOI
TL;DR: A highly sensitive and molecular size-selective method using heteroliganded gold nanoislands and localized surface plasmon resonance (LSPR) to selectively detect SOD1 in the presence of aggregates at the molecular level is described.
Abstract: A highly sensitive and molecular size-selective method for the detection of proteins using heteroliganded gold nanoislands and localized surface plasmon resonance (LSPR) is described. Two different heteroligands with different chain lengths (3-mercaptopionicacid and decanethiol) were used in fabricating nanoholes for the size-dependent separation of a protein in comparison with its aggregate. Their ratios on gold nanoisland were optimized for the sensitive detection of superoxide dismutase (SOD1). This protein has been implicated in the pathology of amyotrophic lateral sclerosis (ALS). Upon exposure of the optimized gold nanoisland to a solution of SOD1 and aggregates thereof, changes in the LSPR spectra were observed which are attributed to the size-selective and covalent chemical binding of SOD1 to the nanoholes. With a lower detection limit of 1.0 ng/ml, the method can be used to selectively detect SOD1 in the presence of aggregates at the molecular level.

12 citations

Journal ArticleDOI
TL;DR: The relationship between plasma characteristics and etch results with various O 2 -gas mixing ratios was also studied in this paper, where it was confirmed that small additions of oxygen into the Cl 2 /O 2 /Ar gas mixtures lead to high selectivity and a good sidewall profile without a fence, referred to as a bull-ear.
Abstract: Inductively coupled plasma etching of platinum with Cl 2 /O 2 /Ar gas chemistries was examined. Plasma characteristics were investigated with increasing O 2 ratios using a Langmuir probe and a quadrupole mass spectrometer. The chemical reaction during the platinum etching was also examined from the chemical binding states of the etched surface by X-ray photoelectron spectroscopy. Additional characterization employed a four-point probe, thin-film thickness measuring system, and scanning electron microscopy. The relationship between plasma characteristics and etch results with various O 2 -gas mixing ratios was also studied. It was confirmed that small additions of oxygen into the Cl 2 /Ar gas mixtures lead to high selectivity and a good sidewall profile without a fence, also referred to as a bull-ear.

12 citations

Journal ArticleDOI
Rifaat Hilal1
TL;DR: In this article, the electron density maps for the heterocycles thiophene, furan, and pyrrole were determined from ab initio 4−31G wavefunctions.
Abstract: Electron density maps for the heterocycles thiophene, furan, and pyrrole are determined from ab initio 4‐31G wavefunctions. The charge distributions in these molecules are analyzed in terms of the total molecular density and difference density maps and their profiles. The atomiclike core, especially the L core of sulfur, is found to play an important role, via its polarization and interaction, in determining the extent and direction of valence density transfer from the carbon to the heteroatom. The changes in the charge distributions that occur in the immediate vicinity of the heteroatoms and the relation of density quantities to binding and antibinding characteristics are discussed. The quantum topological features of the molecular charge distributions of the three heterocycles are analyzed and discussed and the different bonding situations, e.g., ring strain, ionic and covalent binding, etc., are compared in a model‐independent way.

12 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20223
202178
202076
201989
201866
201769