Chiari-Frommel Syndrome

About: Chiari-Frommel Syndrome is a research topic. Over the lifetime, 23 publications have been published within this topic receiving 191 citations.

A syndrome of primary hypothyroidism, amenorrhea and galactorrhea.

Abstract: We have reported a patient with primary hypothyroidism, galactorrhea and amenorrhea and have found 3 similar patients in a review of the literature. All 4 occurred in the postpartum state, and none exhibited evidence of a pituitary tumor. These cases appear to represent a distinct clinical entity. Although certain features suggest the syndrome of “hormonal overlap,” the authors believe the abnormality is inhibition by the hypothyroid state of the hypothalamic center controlling release of prolactin and luteinizing hormone. Supporting evidence for this is reviewed. This syndrome must be distinguished from the Chiari-Frommel syndrome since it is amenable to therapy with thyroid hormone.

Abnormal lactation with Cushing's syndrome--a case report.

Abstract: A 29-yr-old patient with abnormal lactation was studied on several occasions. The onset of abnormal lactation followed a normal pregnancy. During the first hospitalization the sella turcica and various urinary and plasma steroid levels were within normal limits and a diagnosis of Chiari-Frommel syndrome was made. Subsequently, the patient developed headaches and visual disturbances and showed an enlarged sella turcica due to a chromophobe adenoma of the pituitary. At this time urinary steroids and cortisol secretion rate showed marked elevation. This case represents a Chiari-Frommel syndrome which ultimately developed in complex of hyperadrenocorticism, secondary amenorrhea and persistent lactation.

Chiari-Frommel syndrome in a patient with primary adrenocortical insufficiency.

Abstract: For fourteen months post partum a 31-yearold woman had amenorrhea, galactorrhea, hyperpigmentation, and loss of sexual hair. A diagnosis of primary adrenocortical insufficiency was supported by low serum and urinary cortisol, high serum ACTH, circulating adrenal antibodies, aldosterone deficiency, failure to respond to exogenous ACTH, and a normal sella turcica, growth hormone, thyrotropin, and luteinizing and follicle-stimulating hormones. Base-line human prolactin levels were slightly but consistently elevated to 26 to 29 ng per milliliter. Replacement with 37.5 mg of cortisone acetate per day resulted within three weeks in spontaneous resumption of regular menstrual cycles, disappearance of galactorrhea, weight gain and regression of pigmentary changes. Serum ACTH returned to normal, and prolactin levels decreased to 10 to 11 ng per milliliter. Thus, glucocorticoid deficiency due to primary adrenocortical insufficiency can produce persistent prolactin elevation with galactorrhea in the hormona...