Topic
Chromosome
About: Chromosome is a research topic. Over the lifetime, 17538 publications have been published within this topic receiving 660077 citations. The topic is also known as: chromosomes & GO:0005694.
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TL;DR: The data show that more than one specific chromosomal site may be involved in the development of human renal cell carcinomas, and it is proposed that the 3p13-pter segment was identified as the minimal common deletion.
Abstract: The karyotype of 75 sporadic, nonpapillary renal cell carcinomas was analyzed using chromosome banding techniques. Sixty-five tumors had near-diploid stemlines, and ten had near-triploid or near-tetraploid stemlines. Aberration of chromosome 3 was detected in 71 cases. The nonrandom changes on chromosome 3 were monosomy 3, terminal deletions, or unbalanced translocations; the 3p13-pter segment was identified as the minimal common deletion. The rearrangement of chromosome 3p was the only karyotype change in 13 tumors. Abnormalities of chromosome 5 resulting in trisomy for the 5q22-qter region were found in 36 cases, while the loss of 14q22-qter segment was observed in 34 tumors. Trisomy for chromosome 7 was detected in 17 cases, and monosomy 8 and 9 occurred 14 times each. Our data show that more than one specific chromosomal site may be involved in the development of human renal cell carcinomas.
211 citations
TL;DR: Evidence is presented that the Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures and that the complex's role in unchallenged cells is independent of DNA damage.
210 citations
TL;DR: Nonrandom, unbalanced whole-arm translocations of 1q are reported in the cytogenetic evolution of patients with aggressive MM and may be associated with highly decondensed pericentromeric heterochromatin, which may permit recombination and formation of unstable translocation of chromosome 1q.
210 citations
TL;DR: This review will discuss mitotic defects that cause chromosome missegregation, examine components and regulatory mechanisms of the mitotic machine implicated in cancer, and explore mechanisms by which chromosomeMissegregation could lead to cancer.
210 citations
209 citations