Chrysanthemum indicum

About: Chrysanthemum indicum is a research topic. Over the lifetime, 465 publications have been published within this topic receiving 4925 citations. The topic is also known as: Indian chrysanthemum.

Manufacture method Various uses and Extracts for The Development of Anticonspitation Functional food materials from Oriental Herbal Medicines

Abstract: PURPOSE: Provided are antihyperlipidemic concentrate of herbal medicines and the manufacturing method and use thereof. The manufactured antihyperlipidemic concentrate or powder has excellent amelioration effects on hyperlipidemia and hypercholesterol. CONSTITUTION: An antihyperlipidemic concentrate of herbal medicines is manufactured by extracting 5-65 wt.% of Crataegus Pinnatifida Bunge, 5-20 wt.% of Salvia miltorrhiza Bunge, 5-20 wt.% of Pleuropterus multiflorus, 5-15 wt.% of Acanthopanax Senticosus, 5-15 wt.% of Bambusae caulis in Taenian, 5-10 wt.% of Chrysanthemum indicum L., 5-10 wt.% of licorice root and 5 wt.% of Schizandra chinensis Baill with water as a solvent, and concentrating the extract thereof under reduced pressure.

B-ring-homo-tonghaosu, isolated from Chrysanthemum morifolium capitulum, acts as a peroxisome proliferator-activated receptor-γ agonist.

Abstract: The capitula of Chrysanthemum morifolium and C. indicum are used to prepare Chrysanthemi Flos in traditional Japanese Kampo medicine. In our previous study, we reported on the agonistic effect of methanol extract of C. indicum capitulum on peroxisome proliferator-activated receptor (PPAR)-γ. We further isolated (E)-tonghaosu from C. indicum capitulum as one of the active ingredients. In the present study, we aimed to evaluate the PPAR-γ agonistic activity of a methanol extract of C. morifolium capitulum (MCM) in which (E)-tonghaosu could not be detected. MCM exhibited PPAR-γ agonistic activity in a concentration-dependent manner, and at a dose of 100 µg/ml, it showed similar activity to pioglitazone (30 µM), a standard PPAR-γ agonist. Through activity-guided fractionation, we isolated two geometric isomers, (E)- (1) and (Z)-B-ring-homo-tonghaosu (2), as the active ingredients of MCM. Both compounds exerted concentration-dependent PPAR-γ agonistic effects, and 1 had higher activity than 2. At 1.4 µM, 1 had similar activity to pioglitazone (30 µM), which was achieved by 2 at a concentration of 140 µM. Thus, 1 has the potential to become a lead compound for the drug discovery of PPAR-γ agonists. We compared the activities and the contents of (E)-, (Z)-tonghaosu, 1, and 2 among 13 commercial samples of Chrysanthemi Flos, including those derived from both C. morifolium and C. indicum. Their PPAR-γ agonistic activities were not related to the contents of these compounds. 1 and 2 were detected in the samples derived from both species but (E)- and (Z)-tonghaosu were not detected in the samples derived from C. morifolium; hence (E)- and (Z)-tonghaosu can serve as marker compounds to identify the capitula of C. indicum in Chrysanthemi Flos samples.

In vitro antioxidant and antimicrobial activity of anthotaxy extracts from Dendranthema morifolium (Ramat.) Tzvel. and Chrysanthemum indicum L.

Abstract: Dendranthema morifolium (Ramat.) Tzvel. and Chrysanthemum indicum L. are two traditional Chinese medicines, which were often obscure in prescriptions. In this study, the aqueous and ethanolic anthotaxy extracts from D. morifolium (Ramat.) Tzvel. and C. indicum L., were evaluated for their antioxidant and antimicrobial properties. Ethanolic extracts showed higher contents of both total phenolics and flavonoids than aqueous extracts. The total phenolics and flavonoids contents in both aqueous and ethanolic extracts were in the order of D.morifolium (Ramat.) Tzvel. > C. indicum L. Using 1,1-diphenylpicrylhydrazyl (DPPH) assays, the concentrations providing 50% inhibition (IC50) values of aqueous extracts from D.morifolium (Ramat.) Tzvel. and C. indicum L. were 2.26 and 2.93 mg/ml, respectively, whereas the IC50 values of ethanolic extracts were 0.38 and 1.34 mg/ml, respectively. In sum, the antioxidant activities of ethanolic extracts from both D. morifolium (Ramat.) Tzvel.and C. indicum L. were better than aqueous extracts, and in the order of D. morifolium(Ramat.) Tzvel. > C. indicum L. The ethanolic extracts exhibited moderate antimicrobial activities, whereas the aqueous extracts showed poor antimicrobial properties in our test system. Key words: Dendranthema morifolium (Ramat.) Tzvel., Chrysanthemum indicum L., antioxidant activity, antimicrobial activity.

Chrysanthemum indicum suppresses adipogenesis by inhibiting mitotic clonal expansion in 3T3-L1 preadipocytes.

Abstract: Herbs have been of interest to treat diseases, including obesity, owing to their various bioactive constituents that exhibit therapeutic and prophylactic properties. The present study examined the anti-adipogenic effects and mechanisms of Chrysanthemum indicum aqueous extract (CAE) in 3T3-L1 preadipocytes. CAE comprises 1,3-dicaffeoylquinic acid, chlorogenic acid, kaempferol-3-O-glucoside, caffeic acid, and apigenin, which were corresponded with previous reports. CAE inhibited the accumulation of lipid droplets and significantly alleviated the expression of lipogenesis- and adipogenesis-associated biomarkers. Treatment with CAE inhibited the mitotic clonal expansion (MCE), corroborated by cell cycle arrest at the G0 /G1 phase, and mitigated the expression of cell cycle progression-associated proteins and in addition to phosphorylation of MCE-promoting transcription factors. Moreover, CAE downregulated the activation of Akt and extracellular signal-regulated kinase 1/2 signaling pathways. In summary, CAE facilitates adipogenic inhibition during the early phase of differentiation, especially MCE, and its phenolic compounds can contribute to its anti-obesogenic properties. PRACTICAL APPLICATIONS: Chrysanthemum indicum has been mainly used as traditional herbal tea and drinks. Chrysanthemum indicum aqueous extract (CAE) inhibits adipogenesis by suppressing mitotic clonal expansion during the early phase of differentiation in 3T3-L1 preadipocytes. 1,3-Dicaffeoylquinic acid, chlorogenic acid, kaempferol-3-O-glucoside, caffeic acid, and apigenin were detected in CAE. Based on these findings, CAE can be used as nutraceutical agents for prevention and treatment of obesity.

Efficacy of Bioinoculants, Plant Growth Regulators and Nutrients in Prolonging Vase Life of Chrysanthemum indicum L.

Abstract: The present study was undertaken to compare the efficiency of two Arbuscular mycorrhizal (AM) fungi Glomus mosseae (G), Acaulospora laevis (A) along and in combination with Pseudomonas fluorescens (P), Trichoderma viride (T) and growth regulators like salicylic acid and kinetin and nutrients like sucrose and NaCl on the vase life of Chrysanthemum flowers. Different parameters like visible effect, flower diameter, volume of holding solution, vase life and peroxidase activity was recorded at 0, 8 and 16 days of holding cut flowers in 100 ml different solutions. The maximum vase life was observed in T12 (G+A+T) treatment (15.66±0.57), followed by T7 (G+T) 15.33±0.57, T2 (G) 14.66±0.57, T3 (A) 14.33±0.57 and kinetin (14.33±0.57). Triple inoculation of (G+A+T) treated flowers showed lesser peroxidase activity 0.024± 0.004 mg m on 0-day stage 10 to 0.123± 0.004 mg m on 15-day stage, as compared to flower placed in other solutions. So, it is evident from 10 our result that the vase life of Chrysanthemum flowers increased by inoculation of different bioinoculants as compared to the treated with different growth regulators and nutrients.