Topic
Chrysanthemum indicum
About: Chrysanthemum indicum is a research topic. Over the lifetime, 465 publications have been published within this topic receiving 4925 citations. The topic is also known as: Indian chrysanthemum.
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TL;DR: Water extract of Chrysanthemum indicum Linne has the potential as nutri-cosmetic and cosmetic ingredient which possess anti-oxidant and anti-adipogenic effects.
Abstract: Purpose: Chrysanthemum indicum Linne (CI) has been used as a traditional medicine. Although several biological effects of CI have been reported, the precise role and function of CI as nutri-cosmetic and cosmetic materials remain unclear. Therefore, we prepared water extract of Chrysanthemum indicum Linne (CIW). And nutri-cosmetic potential was discussed through evaluation of anti-oxidant, anti- adipogenic in 3T3-L1 cells and regulatory function of skin fibril- related genes in human skin fibroblast (HSF). Methods: The anti- oxidant activity of CIW was evaluated through metal chelating activity and reduction potential. The cytotoxicity of CIW in 3T3-L1 and HSF was evaluated by MTT assay. The anti-adipogenic effect of CIW was examined by Oil Red O (ORO) staining and microscopy observation in 3T3-L1 cells. The mRNA expression levels of skin fibril-related genes in HSF were analyzed by reverse transcription-polymer chain reaction (RT-PCR). Results: The anti-oxidant activity of CIW was increased in a dose dependent manner. The CIW treatment up to 100 µg/mL for 24 h did not affect to the viability of 3T3-L1 cells and HSF. Thus, up to 100 µg/mL of CIW was chosen in cell-based assay. The treatment of 10, 50, and 100 µg/mL CIW significantly inhibited 3T3- L1 adipogenesis by 5.17%, 72.80%, and 104.09%. In addition, up- regulated mRNA expression levels of skin fibril-related genes such as fibronectin and type Ⅰ collagen α2 (COL1A2) were observed in CIW- treated HSF. Conclusion: These results suggest that CIW has the potential as nutri-cosmetic and cosmetic ingredient which possess anti-oxidant and anti-adipogenic effects.
2 citations
Journal Article•
TL;DR: In the liver concentration of cytokines at 5 h post LPS injection, IL-1 andIL-6 decreased with increasing concentration of C. indicum L. extract, however TNF- and IL-10 did not differ significantly the treatment groups.
Abstract: This study for developing a new anti-inflammatory medicine was sought by investigating the antiinflammatory properties of C. indicum L. extract. Rats were treated with either saline (control) or C. indicum L. extract and then injected with LPS. We found that the plasma concentration of IL-1 IL-6, TNF-and IL-10 peaked at 5h after LPS injection, and the plasma concentration of IL-6 and TNF- showed a tendency to decrease, and IL-10 concentration showed a tendency to increase with increasing levels of C. indicum L. extract. In the liver concentration of cytokines at 5 h post LPS injection, IL-1 and IL-6 decreased with increasing concentration of C. indicum L. extract, however TNF- and IL-10 did not differ significantly the treatment groups.
2 citations
01 Nov 2016
2 citations
Patent•
12 Oct 2009
TL;DR: In this paper, a pharmaceutical composition for preventing and treating diabetes and complication of diabetes which contains Chrysanthemum indicum L. extract is provided to widely use for diabetes patients, which is contained in 0.5-50 weight% based on total weight.
Abstract: PURPOSE: A pharmaceutical composition for preventing and treating diabetes and complication of diabetes which contains Chrysanthemum indicum L. extract is provided to widely use for diabetes patients. CONSTITUTION: A pharmaceutical composition for preventing and treating diabetes and complication of diabetes contains Chrysanthemum indicum L. extract. The Chrysanthemum indicum L. extract is contained in 0.5-50 weight% based on total weight. The extract is isolated using low alcohol of 1-4 carbon atoms or their mixture solvent with water, acetone, chloroform, methylenechloride, ether and ethylacetate.
2 citations
01 Jan 2014
TL;DR: In this article, the effect of blanching pretreatment of Chrysanthemum indicum linn on drying performance was investigated and mathematical drying models at a constant air velocity and temperatures (i.e., 1.0 m/s and 50, 60, 70 and 80°C).
Abstract: The aim of this study was to investigate the effect of blanching pretreatment of Chrysanthemum indicum Linn. on drying performance and to develop mathematical drying models at a constant air velocity and temperatures (i.e., 1.0 m/s and 50, 60, 70 and 80°C). The required drying time to reduce moisture content from 6.01 ±0.44 g water/g dry matter of blanched, and 4.59 ±0.27 g water/g dry matter of fresh Chrysanthemum to 0.071 ±0.003 g water/g dry matter were 570, 445, 340 and 220 min, and 620, 480, 370 and 245 min, respectively. Empirical moisture content curves were fitted to the Newton, Page and Henderson and Pabis drying models. The Page model yielded the highest coefficient of determination (R2), the least chi-square and the lowest root mean square error (RMSE). The drying rates of the pre-treated Chrysanthemum were faster than those of untreated samples by 1.41, 1.42, 1.43 and 1.46 folds at 50, 60, 70 and 80°C, respectively. The activation energy for drying of pre-treated and untreated Chrysanthemum were well documented using an exponential expression based on by Arrhenius models and was found to be 30.38 and 33.41 kJ/mol.
2 citations