Topic
Chrysanthemum indicum
About: Chrysanthemum indicum is a research topic. Over the lifetime, 465 publications have been published within this topic receiving 4925 citations. The topic is also known as: Indian chrysanthemum.
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2 citations
Journal Article•
TL;DR: HC-1 is marked with (a) high yield, (b) low toxicity, (c) mild action, and (d) certain hypotensive effects in anesthetized and unanesthetization animals, which may be recommended to clinical trial.
Abstract: Chrysanthemum indicum is effective in lowering blood pressure. Extraction with hot ethanol yielded an active fraction, HC-1. In anesthetized cats, intraduodenal injetions of 50—100 mg/kg of HC-1 produced an average "％ of hypotensive areas" in 2 hours varying from -19％ to -22％. Four normotensive dogs were fed 50, 100, 130 and 150 mg/kg resp., and the diastolic pressure dropped 0, 24, 8 and 36 mm Hg resp. The hypotensive action was slow and lasted more than 2 hours. Three renal hypertensive dogs were fed daily 100 mg/kg in the first 2 weeks, and 200 mg/kg for the 3rd week. Weekly tests on EKG, serum BSP retention, and blood NPN revealed no serious alterations. In two of them the blood pressure was brought down significantly. Daily feeding of 300 mg/kg to one healthy dog for 3 weeks brought forth no grave reactions except vomiting at times. HC-1 is marked with (a) high yield, (b) low toxicity, (c) mild action, and (d) certain hypotensive effects in anesthetized and unanesthetized animals. So it may be recommended to clinical trial.
2 citations
Journal Article•
TL;DR: TFC can inhibit proliferation and induce apoptosis in synovial cells, and exert therapeutical effect on rheumatoid arthritis.
Abstract: OBJECTIVE To investigate the effect on the extract of total flavonoids of Chrysanthemum indicum (TFC) on adjuvant arthritis synovial cells. METHOD SD rats were divided randomly into six groups including normal, model, TFC (84, 168, 336 mg x kg(-1)) and control drug Tripterygium glycosides (30 mg x kg(-1)) groups. Adjuvant arthritis rat model was induced by a single intradermal injection of 0.1 mL of the complete Freund's adjuvant into the right hind feet pads of the SD rats. The proliferation of synoviocyte was measured by MT; The apoptosis rates of synovial cells were evaluated using TUNEL and FCM analysis. RESULT TFC resulted in a dose-dependent way in inhibiting the proliferation of synovial and inducing the apoptosis of synovium and synoviocytes in vivo. CONCLUSION TFC can inhibit proliferation and induce apoptosis in synovial cells, and exert therapeutical effect on rheumatoid arthritis.
2 citations
Patent•
26 Oct 2017
2 citations
01 Jan 2012
TL;DR: An experiment on pinching with 3 replications showed the tallest and the shortest plant was shown without pinching and with pinching, respectively, as well as maximum number of leaves and flowers recorded following pinching.
Abstract: An experiment on pinching (viz. P0; without pinching and P1; with pinching) with 3 replications showed the tallest (37.7 cm) and the shortest plant (33.4 cm) without pinching and with pinching, respectively. Maximum number of leaves (30.1) and flowers (58.7) per plant were recorded following pinching (P1); and minimum number of leaves (26.8) and flowers (37.9) per plant were from without pinching (P0).
2 citations