Topic
Claisen rearrangement
About: Claisen rearrangement is a research topic. Over the lifetime, 3783 publications have been published within this topic receiving 57974 citations.
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TL;DR: In this review article, recent advances in the asymmetric Claisen rearrangement are described.
Abstract: Development of the asymmetric Claisen rearrangement is one of the challenging tasks in synthetic organic chemistry. There have been numerous reports of the asymmetric Claisen rearrangement based on the intramolecular chirality transfer using chiral substrates. On the other hand, reactions of achiral substrates with an external chiral activator have been studied during the last decade. In this review article, recent advances in the asymmetric Claisen rearrangement are described.
178 citations
177 citations
176 citations
TL;DR: A practical method for the diastereoselective generation of two adjacent quarternary stereocenters by combining a copper-catalyzed C-O coupling reaction with a subsequent Claisen rearranged in a one-pot domino process is described.
Abstract: A practical method for the diastereoselective generation of two adjacent quarternary stereocenters by combining a copper-catalyzed C−O coupling reaction with a subsequent Claisen rearrangement in a one-pot domino process is described. Furthermore, an experimentally simple method for the stereoselective synthesis of a variety of different types of vinyl ethers is delineated using the same catalyst system.
167 citations