Clock network

About: Clock network is a research topic. Over the lifetime, 755 publications have been published within this topic receiving 10847 citations. The topic is also known as: clock system.

Extension of a genetic network model by iterative experimentation and mathematical analysis

Abstract: Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex clock network. The first part of the network to be identified, a transcriptional feedback loop comprising TIMING OF CAB EXPRESSION 1 (TOC1), LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), fails to account for significant experimental data. We develop an extended model that is based upon a wider range of data and accurately predicts additional experimental results. The model comprises interlocking feedback loops comparable to those identified experimentally in other circadian systems. We propose that each loop receives input signals from light, and that each loop includes a hypothetical component that had not been explicitly identified. Analysis of the model predicted the properties of these components, including an acute light induction at dawn that is rapidly repressed by LHY and CCA1. We found this unexpected regulation in RNA levels of the evening-expressed gene GIGANTEA (GI), supporting our proposed network and making GI a strong candidate for this component.

Power considerations in the design of the Alpha 21264 microprocessor

Abstract: Power dissipation is rapidly becoming a limiting factor in high performance microprocessor design due to ever increasing device counts and clock rates. The 21264 is a third generation Alpha microprocessor implementation, containing 15.2 million transistors and operating at 600 MHz. This paper describes some of the techniques the Alpha design team utilized to help manage power dissipation. In addition, the electrical design of the power, ground, and clock networks is presented.

A clock network for geodesy and fundamental science.

Abstract: Leveraging the unrivalled performance of optical clocks as key tools for geo-science, for astronomy and for fundamental physics beyond the standard model requires comparing the frequency of distant optical clocks faithfully. Here, we report on the comparison and agreement of two strontium optical clocks at an uncertainty of 5 × 10−17 via a newly established phase-coherent frequency link connecting Paris and Braunschweig using 1,415 km of telecom fibre. The remote comparison is limited only by the instability and uncertainty of the strontium lattice clocks themselves, with negligible contributions from the optical frequency transfer. A fractional precision of 3 × 10−17 is reached after only 1,000 s averaging time, which is already 10 times better and more than four orders of magnitude faster than any previous long-distance clock comparison. The capability of performing high resolution international clock comparisons paves the way for a redefinition of the unit of time and an all-optical dissemination of the SI-second. Comparing the frequency of two distant optical clocks will enable sensitive tests of fundamental physics. Here, the authors compare two strontium optical-lattice clocks 690 kilometres apart to a degree of accuracy that is limited only by the uncertainty of the individual clocks themselves.

A clock distribution network for microprocessors

Abstract: A global clock distribution strategy used on several microprocessor chips is described. The clock network consists of buffered tunable trees or treelike networks, with the final level of trees all driving a single common grid covering most of the chip. This topology combines advantages of both trees and grids. A new tuning method was required to efficiently tune such a large strongly connected interconnect network consisting of up to 6 m of wire and modeled with 50000 resistors, capacitors, and inductors. Variations are described to handle different floor-planning styles. Global clock skew as low as 22 ps on large microprocessor chips has been measured.

Network Features of the Mammalian Circadian Clock

Abstract: The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA (siRNA)-induced dose-dependent changes in gene expression were used to build gene association networks consistent with known biochemical constraints. The use of multiple doses powered the analysis to uncover several novel network features of the circadian clock, including proportional responses and signal propagation through interacting genetic modules. We also observed several examples where a gene is up-regulated following knockdown of its paralog, suggesting the clock network utilizes active compensatory mechanisms rather than simple redundancy to confer robustness and maintain function. We propose that these network features act in concert as a genetic buffering system to maintain clock function in the face of genetic and environmental perturbation.