Showing papers on "Cobalamin transport published in 1985"
TL;DR: The results demonstrate that assumptions that cobalamin is always attached largely to transcobalamin I are not warranted, and appears to be governed by many factors, of which the amounts of the binding proteins is only one.
36 citations
TL;DR: The key role of the cobalamin-binding proteins in meeting the stringent requirements for transport of this essential nutrient is described and the various defects capable of impairing intestinal absorption and transcellular transport are summarized.
Abstract: Highly specialized mechanisms are required for transporting cobalamin (vitamin B12) into and out of mammalian cells. This review describes the key role of the cobalamin-binding proteins in meeting the stringent requirements for transport of this essential nutrient. Also summarized are the various defects capable of impairing intestinal absorption and transcellular transport of cobalamin. Elucidation of these defects proved crucial for our current understanding of normal cobalamin transport mechanisms.
21 citations