Showing papers on "Cobalamin transport published in 1992"
Book•
12 May 1992
TL;DR: Lysosomal Nucleic Acid Catabolism and Carrier Mediated Transport of Nucleosides, and Lysosomal Transport of Sugars: Normal and Pathological.
Abstract: INTRODUCTION (Jess Thoene). APPROACHES TO THE STUDY OF LYSOSOMAL TRANSPORT (Alice Greene and Jerry Schneider). LYSOSOMAL TRANSPORT OF AMINO ACIDS. Lysosomal Cystine Transport (William Gahl). Lysosomal Transport of Small and Large Neutral Amino Acids (Hans Andersson). Lysosomal Transport Systems for Cationic and Anionic Amino Acids: Systems c and d (Ronald Pisoni). LYSOSOMAL TRANSPORT OF INORGANIC IONS. The Transport of Phosphate and Calcium by Human Fibroblast Lysosomes (Ronald Pisoni and Jess Thoene). Lysosomal Sulfate Transport (Jaydutt Vadgama and Adam Jonas). LYSOSOMAL TRANSPORT OF OTHER METABOLITES. Lysosomal Nucleic Acid Catabolism and Carrier Mediated Transport of Nucleosides (Ronald Pisoni and Jess Thoene). Lysosomal Transport of Sugars: Normal and Pathological (Frank Tietze). Lysosomal Cobalamin Transport (Susan Sillaots and David Rosenblatt). TRANSPORT OF MACROMOLECULES TO LYSOSOMES (Hsiang-Kuang Lee and Louis Marzella). PASSIVE DIFFUSION ACROSS THE LYSOSOME MEMBRANE ( John Lloyd). VACUOLES OF PLANTS AND FUNGI (John-Michael Idriss).
20 citations
TL;DR: It is suggested that luminal bile acids optimize the binding of IF-Cbl by the ileal membrane receptor via interactions with a cytosolic factor and thus influence the gastrointestinal absorption of cobalamin.
Abstract: The intrinsic factor (IF)-cobalamin (Cbl) receptor activity in the mucosal homogenates progressively decreased after bile duct ligation in the rat, and 80% of the receptor activity was decreased in 96 h after ligation. The activity was restored to normal values of 5.5-6 pmol of IF-[57Co]Cbl bound/g mucosa when the assays were performed with both conjugated and unconjugated bile acids. When [57Co]Cbl bound to intrinsic factor was orally administered, the tissue levels of [57Co]Cbl were decreased by 75-80% in bile duct-ligated rats. The apical membrane receptor activity was also decreased after bile duct ligation; however, the activity was stimulated twofold by the addition of ileal cytosol and threefold with the addition of both ileal cytosol and taurocholate (1 mM). Enhanced binding of IF-[57Co]Cbl to the apical ileal brush-border membrane occurred with the use of dialyzed ileal cytosol but not with cytosol isolated from duodenal or proximal jejunal mucosa. The enhanced binding obtained with ileal cytosol...
2 citations