Topic
Cognitive decline
About: Cognitive decline is a research topic. Over the lifetime, 29308 publications have been published within this topic receiving 1174689 citations.
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TL;DR: A low-dose regimen of prednisone is not useful in the treatment of AD and subjects treated withprednisone showed behavioral decline compared with those in the placebo group.
Abstract: Background Laboratory and epidemiologic studies suggest that anti-inflammatory/immunosuppressive therapy may be useful in the treatment of AD. In preliminary studies, a regimen of low to moderate dose prednisone was found to suppress peripheral inflammatory markers without adverse effects in subjects with AD. Methods We conducted a randomized, placebo-controlled multicenter trial to determine whether prednisone treatment slowed the rate of cognitive decline in AD. The active treatment regimen consisted of an initial dose of 20 mg of prednisone daily for 4 weeks tapered to a maintenance dose of 10 mg daily for 1 year, followed by gradual withdrawal during an additional 16 weeks. The primary outcome measure was the 1-year change in the cognitive subscale of the AD Assessment Scale. Results A total of 138 subjects were randomized to the drug and placebo groups. There was no difference in cognitive decline between the prednisone and placebo treatment groups in the primary intent-to-treat analysis, or in a secondary analysis considering completers only. Subjects treated with prednisone showed behavioral decline compared with those in the placebo group. Conclusion A low-dose regimen of prednisone is not useful in the treatment of AD.
401 citations
TL;DR: Age-associated intensification of the links among sensory, sensorimotor and cognitive functions observed both correlationally and experimentally may point to common causes influencing all three functions, including an increase in resource overlap, cross-domain resource competition, and compensatory tradeoffs.
400 citations
TL;DR: It is suggested that repeated treatment with estrogen and progesterone initiated within a specific period of time after the loss of ovarian function may be effective at preventing specific negative effects of hormone deprivation on brain aging and cognitive decline.
400 citations
TL;DR: Serial MRI could track disease progression and detect neurodegenerative diseases earlier to allow prompt and specific treatment, and the amount and pattern of excess atrophy might help to predict the underlying pathological process, allowing specific therapies to be started.
400 citations
TL;DR: The extent of innate immune gene upregulation in AD was modest relative to the robust response apparent in the aged brain, consistent with the emerging idea of a critical involvement of inflammation in the earliest stages, perhaps even in the preclinical stage, of AD.
Abstract: Background
This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD).
399 citations