Conditioning

About: Conditioning is a research topic. Over the lifetime, 387 publications have been published within this topic receiving 9809 citations.

Classical Conditioning and Brain Systems: The Role of Awareness

Abstract: Classical conditioning of the eye-blink response, perhaps the best studied example of associative learning in vertebrates, is relatively automatic and reflexive, and with the standard procedure (simple delay conditioning), it is intact in animals with hippocampal lesions. In delay conditioning, a tone [the conditioned stimulus (CS)] is presented just before an air puff to the eye [the unconditioned stimulus (US)]. The US is then presented, and the two stimuli coterminate. In trace conditioning, a variant of the standard paradigm, a short interval (500 to 1000 ms) is interposed between the offset of the CS and the onset of the US. Animals with hippocampal lesions fail to acquire trace conditioning. Amnesic patients with damage to the hippocampal formation and normal volunteers were tested on two versions of delay conditioning and two versions of trace conditioning and then assessed for the extent to which they became aware of the temporal relationship between the CS and the US. Amnesic patients acquired delay conditioning at a normal rate but failed to acquire trace conditioning. For normal volunteers, awareness was unrelated to successful delay conditioning but was a prerequisite for successful trace conditioning. Trace conditioning is hippocampus dependent because, as in other tasks of declarative memory, conscious knowledge must be acquired across the training session. Trace conditioning may provide a means for studying awareness in nonhuman animals, in the context of current ideas about multiple memory systems and the function of the hippocampus.

Probability of shock in the presence and absence of CS in fear conditioning.

Abstract: 2 experiments indicate that CS-US contingency is an important determinant of fear conditioning and that presentation of US in the absence of CS interferes with fear conditioning. In Experiment 1, equal probability of a shock US in the presence and absence of a tone CS produced no CER suppression to CS; the same probability of US given only during CS produced substantial conditioning. In Experiment 2, which explored 4 different probabilities of US in the presence and absence of CS, amount of conditioning was higher the greater the probability of US during CS and was lower the greater the probability of US in the absence of CS; when the 2 probabilities were equal, no conditioning resulted. Two conceptions of Pavlovian conditioning have been distinguished by Rescorla (1967). The first, and more traditional, notion emphasizes the role of the number of pairings of CS and US in the formation of a CR. The second notion suggests that it is the contingency between CS and US which is important. The notion of contingency differs from that of pairing in that it includes not only what events are paired but also what events are not paired. As used here, contingency refers to the relative probability of occurrence of US in the presence of CS as contrasted with its probability in the absence of CS. The contingency notion suggests that, in fact, conditioning only occurs when these probabilities differ; when the probability of US is higher during CS than at other times, excitatory conditioning occurs; when the probability is lower, inhibitory conditioning results. Notice that the probability of a US can be the same in the absence and presence of CS and yet there can be a fair number of CS-US pairings. It is this that makes it possible to assess the relative importance of pairing and contingency in the development of a CR. Several experiments have pointed to the usefulness of the contingency notion. Rescorla (1966) reported a Pavlovian 1This research was supported by Grants MH13415-01 from the National Institute of Mental Health and GB-6493 from the National Science Foundation, as well as by funds from Yale University.

Conditioning and learning

Abstract: in most cases actually fails to supply her own needs. The most striking example of suich failure is that of quinine. India uises 200,000 lb. a year, and needs at least 600,000 lb., bLut the Indian produLction is only 70,000 lb. Discussing the steps necessary to make India selfsupporting in the matter of drugs of vegetable origin, Mr. Ghosh declares that a big co-ordinated effort is needed. First, the cultivation of drugs must be organized, and, secondly, large-scale manufacture is essential, because processes such as the extraction of alkaloids on a commercial scale involve difficult techniques, many of which are trade secrets. In regard to the purification of drugs the important point arises that the Indian population must be provided with drugs at the lowest possible cost. In Europe the prime cost of the drug is usually only a small fraction of the price at which it is sold, and hence more attention is paid to obtaining the purest possible product than to keeping the cost of production as low as possible. This practice has, for example, led to the use of pure quinine salts in preference to the mixed cinchona alkaloids, though the latter are much cheaper, and the most urgent Indian need is for the cheapest effective anti-malarial. The first step towards improving the home production of drugs in India is to establish control over the sale -of drugs. Mr. Ghosh points out that the absence of adequate pharmacy laws makes it impossible to enforce any standards regarding the quality of drUgs sold to the public. The general thesis of his book is that if adequate use were made of the drugs provided by Nature in India the country could be saved a large sum of money and the health of the people greatly improved. Such a development requires, however, a large-scale organization of the growth and manufacture of drugs and the institution of adequate legal control over their sale. Finally he touches on the need for more research on the properties of the lesser-known Indian drugs, and pays a tribute to the work already done in this connexion by Colonel Chopra and his institute.

A selective role for corticosterone in contextual-fear conditioning.

Abstract: The contribution of corticosterone to contextual- and auditory-cue fear conditioning was examined. Adrenalectomized rats showed reduced contextual-fear conditioning when tested 24 hr after conditioning; however, neither immediate contextual- nor auditory-cue fear conditioning was impaired. Contextual-fear conditioning in adrenalectomized rats with corticosterone replacement during the 4-day interval separating surgery and conditioning matched the level of controls. Moreover, rats exposed to the context prior to adrenalectomy showed normal long-term contextual-fear conditioning. Corticosterone replacement administered after the conditioning episode also negated the effects of adrenalectomy. Thus, corticosterone's role in fear conditioning is selective: It appears to contribute to the neural processes that support the consolidation of a long-term memory representation of the context.