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Showing papers on "Contrast (vision) published in 2012"


Journal ArticleDOI
TL;DR: The proposed IQA scheme is designed to follow the masking effect and visibility threshold more closely, i.e., the case when both masked and masking signals are small is more effectively tackled by the proposed scheme.
Abstract: In this paper, we propose a new image quality assessment (IQA) scheme, with emphasis on gradient similarity. Gradients convey important visual information and are crucial to scene understanding. Using such information, structural and contrast changes can be effectively captured. Therefore, we use the gradient similarity to measure the change in contrast and structure in images. Apart from the structural/contrast changes, image quality is also affected by luminance changes, which must be also accounted for complete and more robust IQA. Hence, the proposed scheme considers both luminance and contrast-structural changes to effectively assess image quality. Furthermore, the proposed scheme is designed to follow the masking effect and visibility threshold more closely, i.e., the case when both masked and masking signals are small is more effectively tackled by the proposed scheme. Finally, the effects of the changes in luminance and contrast-structure are integrated via an adaptive method to obtain the overall image quality score. Extensive experiments conducted with six publicly available subject-rated databases (comprising of diverse images and distortion types) have confirmed the effectiveness, robustness, and efficiency of the proposed scheme in comparison with the relevant state-of-the-art schemes.

663 citations


Journal ArticleDOI
TL;DR: Psychometric functions for contrast sensitivity fitted for the regular and irregular conditions indicated that temporal expectation modulates perceptual processing by enhancing the contrast sensitivity of visual targets, and these effects support the idea that temporal structure of external events can entrain the attentional focus and psychophysical data, optimizing the processing of relevant sensory information.
Abstract: It is increasingly clear that we extract patterns of temporal regularity between events to optimize information processing. Whereas some of the mechanisms for facilitating action preparation and execution have been well documented, much less is understood about whether and how temporal expectations influence visual perception. We used a psychophysical paradigm and computational modeling to investigate the mechanisms by which temporal expectation can modulate visual perception. Visual targets appeared in a stream of noise-patches separated by a fixed (400 ms regular condition) or jittered (200/300/400/500/600 ms irregular condition) intervals. Targets were visual gratings tilted 45° clockwise or counter-clockwise, presented at one of seven contrast levels. Human observers were required to perform an orientation discrimination (i.e., left or right). Psychometric functions for contrast sensitivity fitted for the regular and irregular conditions indicated that temporal expectation modulates perceptual processing by enhancing the contrast sensitivity of visual targets. This increase in the signal strength was accompanied by a reduction in reaction times. A diffusion model indicated that rhythmic temporal expectation enhanced the signal-to-noise gain of the sensory evidence upon which decisions were made. These effects support the idea that temporal structure of external events can entrain the attentional focus and psychophysical data, optimizing the processing of relevant sensory information.

246 citations


Journal ArticleDOI
TL;DR: It is suggested that frequency modulation improves the encoding of a wide range of brightness levels without a loss of spatial resolution.
Abstract: PURPOSE. In an effort to restore functional form vision, epiretinal prostheses that elicit percepts by directly stimulating remaining retinal circuitry were implanted in human subjects with advanced retinitis pigmentosa RP). In this study, manipulating pulse train frequency and amplitude had different effects on the size and brightness of phosphene appearance. METHODS. Experiments were performed on a single subject with severe RP (implanted with a 16-channel epiretinal prosthesis in 2004) on nine individual electrodes. Psychophysical techniques were used to measure both the brightness and size of phosphenes when the biphasic pulse train was varied by either modulating the current amplitude (with constant frequency) or the stimulating frequency (with constant current amplitude). RESULTS. Increasing stimulation frequency always increased brightness, while having a smaller effect on the size of elicited phosphenes. In contrast, increasing stimulation amplitude generally increased both the size and brightness of phosphenes. These experimental findings can be explained by using a simple computational model based on previous psychophysical work and the expected spatial spread of current from a disc electrode. CONCLUSIONS. Given that amplitude and frequency have separable effects on percept size, these findings suggest that frequency modulation improves the encoding of a wide range of brightness levels without a loss of spatial resolution. Future retinal prosthesis designs could benefit from having the flexibility to manipulate pulse train amplitude and frequency independently (clinicaltrials.gov number, NCT00279500). (Invest Ophthalmol Vis Sci. 2012;53:205‐214) DOI:10.1167/iovs.118401

132 citations


Journal ArticleDOI
TL;DR: The pupillary physiological response reflects the subjective perception of light and supports the idea that the brain's visual circuitry is shaped by visual experience with images and their possible sources.
Abstract: We recorded by use of an infrared eye-tracker the pupil diameters of participants while they observed visual illusions of lightness or brightness. Four original illusions {based on Gaetano Kanisza's [Kanizsa G (1976) Subjective contours. Sci Am 234:48-52] and Akiyoshi Kitaoka's [Kitaoka A. (2005) Trick Eyes (Barnes & Noble, New Providence, NJ).] examples} were manipulated to obtain control conditions in which the perceived illusory luminance was either eliminated or reduced. All stimuli were equiluminant so that constrictions in pupillary size could not be ascribed to changes in light energy. We found that the pupillary diameter rapidly varied according to perceived brightness and lightness strength. Differences in local contrast information could be ruled out as an explanation because, in a second experiment, the observers maintained eye fixation in the center of the display; thus, differential stimulation of the fovea by local contrast changes could not be responsible for the pupillary differences. Hence, the most parsimonious explanation for the present findings is that pupillary responses to ambient light reflect the perceived brightness or lightness of the scene and not simply the amount of physical light energy entering the eye. Thus, the pupillary physiological response reflects the subjective perception of light and supports the idea that the brain's visual circuitry is shaped by visual experience with images and their possible sources.

127 citations


Journal ArticleDOI
TL;DR: It is found that the mouse contrast response function is similar in shape to other species, and mouse acuity is modest, with an upper limit near 0.5 cycles/°, consistent with prior data.
Abstract: To understand how activity in mammalian neural circuits controls behavior, the mouse is a promising model system due to the convergence of genetic, optical, and physiological methods. The ability to control and quantify behavior precisely is also essential for these studies. We developed an operant visual detection paradigm to make visual psychophysical measurements: head-fixed mice make responses by pressing a lever. We designed this task to permit neurophysiological studies of behavior in cerebral cortex, where activity is variable from trial to trial and neurons encode many types of information simultaneously. To study neural responses in the face of this complexity, we trained mice to do a task where they perform hundreds of trials daily and perceptual thresholds can be measured. We used this task to measure both visual acuity and the minimum detectable contrast in behaving mice. We found that the mouse contrast response function is similar in shape to other species. They can detect low-contrast stimuli, with a peak contrast threshold of 2%, equivalent to ∼15° eccentric in human vision. Mouse acuity is modest, with an upper limit near 0.5 cycles/°, consistent with prior data.

114 citations


Journal ArticleDOI
TL;DR: FDT perimetry and other visual function tests reveal an expanded range of diabetes induced retinal damage even in patients with good visual acuity, including inner retinal and outer retinal functions exhibited impairment related to NPDR.
Abstract: Aims To determine the effect of diabetes on inner and outer retinal function in persons with diabetes and no clinically detectable retinopathy or with non-proliferative diabetic retinopathy (NPDR). Methods Visual function was assessed in 18 adults with normal retinal health, 23 adults with diabetes and 35 adults with NPDR and normal visual acuity. Contrast sensitivity and frequency doubling technology (FDT) sensitivity were used to assess ganglion cell function. Acuity, dark adaptation, light-adapted visual sensitivity and dark-adapted visual sensitivity were measured to evaluate cone and rod photoreceptor visual function. The presence and severity of diabetic retinopathy was determined by grading of 7-field stereoscopic fundus photographs using the Early Treatment Diabetic Retinopathy Study grading system. Results Participants with NPDR exhibited impairment of all measured visual functions in comparison with the normal participants. Inner retinal function measured by FDT perimetry was the most impaired visual function for patients with NPDR, with 83% of patients exhibiting clinically significant impairment. Rod photoreceptor function was grossly impaired, with almost half of the patients with NPDR exhibiting significantly impaired dark-adapted visual sensitivity. Conclusion Both inner retinal and outer retinal functions exhibited impairment related to NPDR. FDT perimetry and other visual function tests reveal an expanded range of diabetes induced retinal damage even in patients with good visual acuity.

107 citations


Journal ArticleDOI
TL;DR: An improved algorithm based on the contrast mechanism of human visual system (HVS) for infrared small target detection in an image with complicated background is proposed, which demonstrates its superior and reliable detection performance by high detection rate and low false alarm rate.

106 citations


Journal ArticleDOI
TL;DR: The results suggest that attention plays an important role in contrast discrimination based on V1 activities that are influences by gamma range tACS stimulation.

97 citations


Journal ArticleDOI
TL;DR: Components of the earliest part of the visual response in the SC provide important building blocks for the neural basis of the sensory–motor transformation, highlighting a critical link between the properties of theVisual response and saccade behavior.
Abstract: Here we examined the influence of the visual response in the superior colliculus (SC) (an oculomotor control structure integrating sensory, motor and cognitive signals) on the development of the motor command that drives saccadic eye movements in monkeys. We varied stimulus luminance to alter the timing and magnitude of visual responses in the SC and examined how these changes correlated with resulting saccade behavior. Increasing target luminance resulted in multiple modulations of the visual response, including increased magnitude and decreased response onset latency. These signal modulations correlated strongly with changes in saccade latency and metrics, indicating that these signal properties carry through to the neural computations that determine when, where and how fast the eyes will move. Thus, components of the earliest part of the visual response in the SC provide important building blocks for the neural basis of the sensory-motor transformation, highlighting a critical link between the properties of the visual response and saccade behavior.

87 citations


Journal ArticleDOI
23 Feb 2012-Neuron
TL;DR: Genetically encoded reporters are used to image synaptic transmission across a population of sensory neurons—bipolar cells in the retina of live zebrafish to generate a triphasic tuning curve with distinct maxima and minima.

83 citations


Journal ArticleDOI
TL;DR: The results suggest that interocular suppression is stronger in strabismic than in anisometropic amblyopia, and contrast interference thresholds were significantly lower in the strabistic group than in the anisometricropic and control group.

Journal ArticleDOI
TL;DR: Image contrast on PMMR depends on the temperature of a corpse, and Radiologists involved in post mortem imaging must be aware of temperature-related changes in MR image contrast to preserve technical quality.

Journal ArticleDOI
TL;DR: Results show an improvement in correlation between measured contrast and observers perceived contrast when the variance of the three color channels separately is used as weighting parameters for local contrast maps, which indicates that further work on contrast measures should account for the global impression of the image while preserving the local information.

Journal ArticleDOI
01 Nov 2012
TL;DR: This work is the first to account for the interplay of luminance contrast (magnitude/frequency) and disparity and its model predicts the human response to complex stereo-luminance images.
Abstract: Binocular disparity is one of the most important depth cues used by the human visual system. Recently developed stereo-perception models allow us to successfully manipulate disparity in order to improve viewing comfort, depth discrimination as well as stereo content compression and display. Nonetheless, all existing models neglect the substantial influence of luminance on stereo perception. Our work is the first to account for the interplay of luminance contrast (magnitude/frequency) and disparity and our model predicts the human response to complex stereo-luminance images. Besides improving existing disparity-model applications (e.g., difference metrics or compression), our approach offers new possibilities, such as joint luminance contrast and disparity manipulation or the optimization of auto-stereoscopic content. We validate our results in a user study, which also reveals the advantage of considering luminance contrast and its significant impact on disparity manipulation techniques.

Journal ArticleDOI
30 Oct 2012-eLife
TL;DR: It is demonstrated for the first time that perceived speed depends on the spatial distribution of contrast over the visual scene rather than the global level of contrast per se, casting new light on how reduced visibility conditions affect perceived speed.
Abstract: Visual speed is believed to be underestimated at low contrast, which has been proposed as an explanation of excessive driving speed in fog. Combining psychophysics measurements and driving simulation, we confirm that speed is underestimated when contrast is reduced uniformly for all objects of the visual scene independently of their distance from the viewer. However, we show that when contrast is reduced more for distant objects, as is the case in real fog, visual speed is actually overestimated, prompting drivers to decelerate. Using an artificial anti-fog-that is, fog characterized by better visibility for distant than for close objects, we demonstrate for the first time that perceived speed depends on the spatial distribution of contrast over the visual scene rather than the global level of contrast per se. Our results cast new light on how reduced visibility conditions affect perceived speed, providing important insight into the human visual system.DOI:http://dx.doi.org/10.7554/eLife.00031.001.

Journal ArticleDOI
TL;DR: In this article, the association between retinal nerve fibre layer thickness and total macular volume (TMV) as measured by optical coherence tomography, and contrast sensitivity measured by Functional Acuity Contrast Testing (FACT) in relapsing-remitting multiple sclerosis was investigated.
Abstract: Objectives To analyse the association between retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) as measured by optical coherence tomography, and contrast sensitivity (CS) measured by Functional Acuity Contrast Testing (FACT) in relapsing-remitting multiple sclerosis; and to investigate whether FACT testing by a contrast box device is feasible in multiple sclerosis (MS). Methods fact was performed using the Optec 6500 P vision testing system with best correction under photopic and mesopic conditions without glare. The Area Under the Log Contrast Sensitivity Function (AUC) was calculated. RNFLT and TMV were assessed by Stratus optical coherence tomography. All participants underwent visual acuity testing (Snellen), spherical refractive error testing and cylindrical refractive error testing. Results 85 relapsing-remitting multiple sclerosis patients (170 eyes) and 35 healthy controls (HC, 70 eyes) were measured. AUC Day and Night were lower in MS than in HC (p Conclusion (1) Contrast sensitivity is reduced in MS versus HC; (2) RNFL and TMV as morphological measures of retinal axonal loss are predictors of contrast sensitivity as a functional visual parameter in MS but not in HC; and (3) FACT with the contrast box is a novel, feasible and rapid method to assess contrast sensitivity in MS.

Journal ArticleDOI
TL;DR: Average reduction in reading speed caused by a difference in letter contrast between 100% and 20% is significantly more apparent in patients with glaucoma when compared with visually healthy people with a similar age and similar cognitive/reading ability.
Abstract: Purpose.Past research has not fully ascertained the extent to which people with glaucoma have difficulties with reading. This study measures change in reading speed when letter contrast is reduced, to test the hypothesis that patients with glaucoma are more sensitive to letter contrast than

Journal ArticleDOI
TL;DR: The mGCC thickness could be a structural parameter for detecting preperimetric glaucoma and the thicknesses of the peripapillary retinal nerve fiber layer were significantly correlated with the total deviation in the visual field parameters of the corresponding area.
Abstract: PURPOSE To compare the thicknesses of the macular ganglion cell complex (mGCC), the entire macular retina, and the peripapillary retinal nerve fiber layer (ppRNFL) in the apparently normal visual field of glaucomatous eyes with hemifield defects with thicknesses in normal eyes. In addition, to evaluate the relationship between the structural and retinal sensitivity parameters by standard automated perimetry. METHODS This single institution study included 50 eyes of 50 glaucoma patients with visual field defects restricted to the superior or inferior hemifield, in addition to 25 eyes of 25 normal controls matched for age, sex, and refractive errors. We measured the thickness of the 3 areas of interest using the automatic algorithm of a spectral-domain optical coherence tomography device. We subsequently compared the difference in these values between the defective and normal hemifields. Furthermore, each optical coherence tomography parameter was correlated with the total deviation values of the parameters in the Humphrey visual field corresponding to each hemisphere. RESULTS The thickness of the mGCC in the normal hemifield of the glaucomatous eyes was significantly less than in normal eyes. In contrast, the total thickness of the macular retinas between the glaucomatous and normal eyes showed no significant difference. In addition, the thicknesses of the mGCC and ppRNFL in the normal hemisphere of the glaucomatous eyes were significantly correlated with the total deviation in the visual field parameters of the corresponding area. CONCLUSIONS In addition to ppRNFL thickness, the mGCC thickness could be a structural parameter for detecting preperimetric glaucoma.

Journal ArticleDOI
TL;DR: The results support the notion that early spatial filtering can provide a unified account of both the constancy in the perceived surface reflectance against mean illuminance and the inconstancy for higher-order illumination statistics.

Book ChapterDOI
27 Apr 2012
TL;DR: The experimental results of proposed LCM-CLAHE method show that this method provides better contrast enhancement with preserving all the local information of the mammogram images.
Abstract: Optimal Contrast enhancement for detection of masses and micro calcification of mammogram images using Contrast Limited Adaptive Histogram Equalization (CLAHE) based on local contrast modification (LCM) is presented in this paper. The LCM-CLAHE is proposed to highlight the finer hidden details in mammogram images and to adjust the level of contrast enhancement. The proposed method is tested for mammographic images from MIAS database. The performance of the proposed method is obtained using Peak Signal to Noise Ratio (PSNR). The results are compared with other standard enhancement techniques such as Histogram Equalization, Unsharp Masking (USM) and CLAHE. The experimental results of proposed method show that this method provides better contrast enhancement with preserving all the local information of the mammogram images.


Journal ArticleDOI
TL;DR: The hypothesis that the eye can differentiate between hyperopic and myopic defocus on the basis of the effects of change in luminance or color contrast is supported.
Abstract: As the eye changes focus, the resulting changes in cone contrast are associated with changes in color and luminance. Color fluctuations should simulate the eye being hyperopic and make the eye grow in the myopic direction, while luminance fluctuations should simulate myopia and make the eye grow in the hyperopic direction. Chicks without lenses were exposed daily (9 a.m. to 5 p.m.) for three days on two consecutive weeks to 2 Hz sinusoidally modulated illumination (mean illuminance of 680 lux) to one of the following: in-phase modulated luminance flicker (LUM), counterphase-modulated red/green (R/G Color) or blue/yellow flicker (B/Y Color), combined color and luminance flicker (Color + LUM), reduced amplitude luminance flicker (Low LUM), or no flicker. After the three-day exposure to flicker, chicks were kept in a brooder under normal diurnal lighting for four days. Changes in the ocular components were measured with ultrasound and with a Hartinger Coincidence Refractometer (aus Jena, Jena, East Germany. After the first three-day exposure, luminance flicker produced more hyperopic refractions (LUM: 2.27 D) than did color flicker (R/G Color: 0.09 D; B/Y Color: -0.25 D). Changes in refraction were mainly due to changes in eye length, with color flicker producing much greater changes in eye length than luminance flicker (R/G Color: 102 μm; B/Y Color: 98 μm; LUM: 66 μm). Our results support the hypothesis that the eye can differentiate between hyperopic and myopic defocus on the basis of the effects of change in luminance or color contrast.

Journal ArticleDOI
TL;DR: In this paper, a modified commercially available optomotor device (OptoMotry®), virtual three-dimensional gratings of variable spatial frequency or contrast were presented to adult zebrafish.
Abstract: Background The aim of this study was to evaluate the visual acuity of adult zebrafish by assessing the optokinetic reflex. Using a modified commercially available optomotor device (OptoMotry®), virtual three-dimensional gratings of variable spatial frequency or contrast were presented to adult zebrafish. In a first experiment, visual acuity was evaluated by changing the spatial frequency at different angular velocities. Thereafter, contrast sensitivity was evaluated by changing the contrast level at different spatial frequencies.

Journal ArticleDOI
TL;DR: The present results, which reflect IOL characteristics in optics, profile, and add power, may contribute to help surgeons decide on the type of IOL most suitable for each patient, especially those with high visual demands at near and intermediate distances.
Abstract: PurposeThis prospective, randomized, double-masked, clinical trial was designed to evaluate visual acuity, contrast sensitivity, subjective quality of vision, and quality of life in 47 patients sym...

Journal ArticleDOI
TL;DR: The vast potential of binocular AO vision testing in understanding the impact of ocular optics on habitual binocular vision is demonstrated by constructing a binocular adaptive optics (AO) vision simulator.
Abstract: Although the ocular higher order aberrations degrade the retinal image substantially, most studies have investigated their effect on vision only under monocular conditions. Here, we have investigated the impact of binocular higher order aberration correction on visual performance and binocular summation by constructing a binocular adaptive optics (AO) vision simulator. Binocular monochromatic aberration correction using AO improved visual acuity and contrast sensitivity significantly. The improvement however, differed from that achieved under monocular viewing. At high spatial frequency (24 c/deg), the monocular benefit in contrast sensitivity was significantly larger than the benefit achieved binocularly. In addition, binocular summation for higher spatial frequencies was the largest in the presence of subject’s native higher order aberrations and was reduced when these aberrations were corrected. This study thus demonstrates the vast potential of binocular AO vision testing in understanding the impact of ocular optics on habitual binocular vision.

Journal Article
TL;DR: Visual acuity and contrast sensitivity measurements in adult zebrafish with the OptoMotry® device are feasible and reveal a remarkably higher VA compared to larvalZebrafish and mice.
Abstract: BackgroundThe aim of this study was to evaluate the visual acuity of adult zebrafish by assessing the optokinetic reflex. Using a modified commercially available optomotor device (OptoMotry®), virtual three-dimensional gratings of variable spatial frequency or contrast were presented to adult zebrafish. In a first experiment, visual acuity was evaluated by changing the spatial frequency at different angular velocities. Thereafter, contrast sensitivity was evaluated by changing the contrast level at different spatial frequencies.ResultsAt the different tested angular velocities (10, 15, 20, 25, and 30 d/s) and a contrast of 100%, visual acuity values ranged from 0.56 to 0.58 c/d. Contrast sensitivity measured at different spatial frequencies (0.011, 0.025, 0.5, 0.1, 0.2, 0.3, 0.4, 0.5 and 0.55 c/d) with an angular velocity of 10 d/s and 25 d/s revealed an inverted U-shaped contrast sensitivity curve. The highest mean contrast sensitivity (±SD) values of 20.49 ± 4.13 and 25.24 ± 8.89 were found for a spatial frequency of 0.05 c/d (angular velocity 10 d/s) and 0.1 c/d (angular velocity 25 d/s), respectively.ConclusionsVisual acuity and contrast sensitivity measurements in adult zebrafish with the OptoMotry® device are feasible and reveal a remarkably higher VA compared to larval zebrafish and mice.

Journal ArticleDOI
TL;DR: Physical and clinical research currently focuses on this technology also referred to as spectral imaging or contrast enhanced spectral mammography (CESM) to allow visualization of low concentration of iodine with only a modest increase in radiation exposure.

Patent
Gabriel Cohen1, Michael A. Cleron1
24 Oct 2012
TL;DR: In this paper, a particular contrast level may be selected based on the detected ambient lighting conditions, e.g., by mapping various contrast levels to preconfigured ambient lighting levels.
Abstract: Display functions in an electronic device may comprise combining runtime color adjustments with brightness adjustments triggered by ambient light detection. Light sensors may be utilized to detect ambient lighting conditions, which may cause adjustment of brightness level applicable to a display (or screen) of the electronic device. The adjustment of brightness level may then be combined with adjustment of contrast level that may also be applicable to display functions. In this regard, a particular contrast level may be selected based on the detected ambient lighting conditions—e.g., by mapping various contrast levels to preconfigured ambient lighting levels. The contrast adjustment may comprise adjusting colors and/or sharpness. Using contrast adjustments, in conjunction with the brightness adjustments, may allow for achieving the same levels of readability with less brightness, and/or for increased readability with the same brightness.

Journal ArticleDOI
TL;DR: The present findings can be used as a reference guide for contrast sensitivity in a general population and for comparison in future studies because of the wide range variability among people with normal vision that increased at higher spatial frequencies.

Journal ArticleDOI
TL;DR: It is hypothesized that dynamic visual processes, such as motion perception, may be more vulnerable to slowed conduction in the optic nerve, and consequently be better associated with projection rates.
Abstract: Objective: Visual Evoked Potentials (VEPs) following optic neuritis (ON) remain chronically prolonged, although standard visual tests indicate full recovery. We hypothesized that dynamic visual processes, such as motion perception, may be more vulnerable to slowed conduction in the optic nerve, and consequently be better associated with projection rates. Methods: Twenty-one patients with acute unilateral, first-ever ON were studied during 1 year. Static visual functions (visual acuity, color perception, visual field, and contrast sensitivity), dynamic visual functions (motion perception), and VEPs were assessed repeatedly. Results: Visual and electrophysiological measurements reached maximal performance 4 months following the acute phase, with no subsequent improvement. Whereas VEP amplitude and static visual functions recovered, VEP latency remained significantly prolonged, and motion perception remained impaired throughout the 12-month period. A strong correlation was found between VEP latencies and motion perception. Visual performance at 1 month was strongly predictive of visual outcome. For static functions, patients who showed partial recovery at 1 month subsequently achieved full recovery. For dynamic functions, the rate of improvement was constant across patients, independent of the initial deficit level. Interpretation: Conduction velocity in the visual pathways correlated closely with dynamic visual functions, implicating the need for rapid transmission of visual input to perceive motion. Motion perception level may serve as a tool to assess the magnitude of myelination in the visual pathways. The constancy across patients may serve as a baseline to assess the efficacy of currently developing neuroprotective and regenerative therapeutic strategies, targeting myelination in the central nervous system. ANN NEUROL 2012