Topic
Controlled release
About: Controlled release is a research topic. Over the lifetime, 20521 publications have been published within this topic receiving 563480 citations.
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TL;DR: This review presents the outstanding contributions in field of biodegradable microspheres as protein delivery systems, their methods of preparation, drug release, stability, interaction with immune system and regulatory considerations.
826 citations
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21 Jul 1988TL;DR: In this paper, a formulation for systemic delivery and controlled release of a trophic factor is described, which consists of a glycolipid carrier component which delivers trophics such as nerve growth factor to a target organ.
Abstract: A formulation is described for systemic delivery and controlled release of a trophic factor. The formulation comprises a glycolipid carrier component which delivers trophic factor, such as nerve growth factor, to a target organ. The glycolipid carrier protects the trophic factor from degradation by enzymes typically endogenous to the human body.
793 citations
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29 May 1995
TL;DR: In this paper, compositions and dosage forms containing moguisteine and having controlled release properties, methods for using such compositions, dosage forms and methods for making them are discussed. But no methods for synthesizing them are given.
Abstract: Disclosed are compositions and dosage forms containing moguisteine and having controlled release properties, methods for using such compositions and dosage forms and methods for making them.
791 citations
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TL;DR: Recent advances in stimuli-responsive block copolymer assemblies which are responsive to tumor and intracellular microenvironments and their applications in anticancer drug delivery and enhanced imaging sensitivity are summarized.
Abstract: Self-assembled nanostructures of amphiphilic and double hydrophilic block copolymers have been increasingly utilized as potent polymeric nanocarriers of therapeutic drugs, genes, bioactive molecules, and imaging/contrast agents due to improved water solubility, bioavailability, and extended blood circulation duration. Though passive and active targeted drug delivery strategies have long been proposed to promote desirable drug accumulation specifically at the disease sites, the introduction of stimuli-responsiveness into self-assembled block copolymer nanocarriers can additionally lead to controlled/triggered release of therapeutic/imaging agents into target pathological tissues and cells, with concomitant advantages of enhanced delivery efficiency and therapeutic efficacy. Appropriately designed stimuli-responsive block copolymer assemblies can exhibit chemical structure transformation, microstructural rearrangement and inversion, or even disassembly into unimers or smaller ones under external stimuli such as pH, temperature, ion strength, redox potential, light, electric, and magnetic fields, and specific bioactive molecules and metabolites. Compared to normal tissues, pathological sites such as tumor tissues typically exhibit vascular abnormalities, weak acidity (∼pH 6.8), abnormal temperatures, over-expressed proteins and enzymes, hypoxia, high levels of metabolites and reactive small molecule species, etc. Moreover, upon cellular uptake, drug-loaded polymeric nanocarriers will be subjected to intracellular pH gradients (pH 5.9–6.2 in early endosomes and pH 5.0–5.5 in late endosomes and lysosomes) and redox and H2O2 gradients within different cell organelles and the cytosol. Thus, block copolymer nanocarriers responsive to the above described bio-relevant stimuli or biochemical signals characteristic of pathologic tissues and cells will provide an alternative type of “active targeting” strategy, which can be utilized to further boost therapeutic efficacy and imaging sensitivity via disease site-specific delivery and controlled release. A variety of extracellular or intracellular stimuli innate to disease sites, such as mildly acidic pH, temperature, enzymes (matrix metalloproteinase, β-glucuronidase, and phosphatase), oxidative/reductive microenvironments, and abnormal levels of bioactive molecules or metabolites, have been utilized for this purpose. In this review, we summarize recent advances in stimuli-responsive block copolymer assemblies which are responsive to tumor and intracellular microenvironments and their applications in anticancer drug delivery and enhanced imaging sensitivity.
783 citations
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29 Jul 1993
TL;DR: An implant and method using microparticles to provide a controlled, sustained release, and improved cellular uptake, of chemotherapeutic agents is described in this paper, where the implant is implanted in a human.
Abstract: An implant and method is disclosed using microparticles to provide a controlled, sustained release, and improved cellular uptake, of chemotherapeutic agents.
781 citations