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Corynebacterium glutamicum
About: Corynebacterium glutamicum is a research topic. Over the lifetime, 3719 publications have been published within this topic receiving 113882 citations.
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TL;DR: Small mobilizable vectors based on the Escherichia coli plasmids pK18 and pK19 can be transferred by RP4-mediated conjugation into a wide range of Gram- and Gram+ bacteria, and should facilitate gene disruption and allelic exchange by homologous recombination.
2,587 citations
TL;DR: These analyses confirm the taxonomic position of C. glutamicum as related to Mycobacteria and show a broad metabolic diversity as expected for a bacterium living in the soil.
948 citations
TL;DR: For almost 50 years now, biotechnological production processes have been used for industrial production of amino acids, and the use of enzymes and whole cell biocatalysts has proven particularly valuable in production of both proteinogenic and nonproteinogenic l-amino acids.
Abstract: For almost 50 years now, biotechnological production processes have been used for industrial production of amino acids. Market development has been particularly dynamic for the flavor-enhancer glutamate and the animal feed amino acids L: -lysine, L: -threonine, and L: -tryptophan, which are produced by fermentation processes using high-performance strains of Corynebacterium glutamicum and Escherichia coli from sugar sources such as molasses, sucrose, or glucose. But the market for amino acids in synthesis is also becoming increasingly important, with annual growth rates of 5-7%. The use of enzymes and whole cell biocatalysts has proven particularly valuable in production of both proteinogenic and nonproteinogenic L: -amino acids, D: -amino acids, and enantiomerically pure amino acid derivatives, which are of great interest as building blocks for active ingredients that are applied as pharmaceuticals, cosmetics, and agricultural products. Nutrition and health will continue to be the driving forces for exploiting the potential of microorganisms, and possibly also of suitable plants, to arrive at even more efficient processes for amino acid production.
723 citations
30 Mar 2005
TL;DR: Part I: History A Short History of the Birth of the Amino Acid Industry in Japan, S. Kinoshita and Part II: Taxonomy Corynebacterium Taxonomy, W.D. Liebl.
Abstract: Part I: History A Short History of the Birth of the Amino Acid Industry in Japan, S. Kinoshita Part II: Taxonomy Corynebacterium Taxonomy, W. Liebl Part III: Genome, Plasmids and Gene Expression The Genomes of Amino Acid-producing Corynebacteria, J. Kalinowski Native Plasmids of Amino Acid-producing Corynebacteria, A. Tauch Regulation of Gene Expression, M. Patek Proteomics, S. Schaffer and A. Burkovski Part IV: Transport The Cell Envelope of Corynebacteria, M. Daffe Genomic Analyses of Transporter Proteins in Corynebacterium glutamicum and Corynebacterium efficiens, B. Winnen, J. Felce, and M. H. Saier, Jr. Export of Amino Acids and Other Solutes, L. Eggeling Part V: Physiology and Regulation Central Metabolism: Sugar Uptake and Conversion, A. Yokota and N.D. Lindley Central Metabolism: Tricarboxylic Acid Cycle and Anaplerotic Reactions, B. Eikmanns Metabolic Flux Analysis in Corynebacterium glutamicum, C. Wittmann and A.A. De Graaf Respiratory Energy Metabolism, M. Bott and A. Niebisch Nitrogen Metabolism and Its Regulation, A. Burkovski Sulfur Metabolism and Regulation, H.-S. Lee Phosphorus Metabolism, V.F. Wendisch and M. Bott Vitamin Synthesis: Carotenoids, Biotin, and Pantothenate, G. Sandmann and H. Yukawa Osmoregulation, S. Morbach and R. Kramer Part VI: Synthesis and Production L-Glutamate Production, E. Kimura L-Lysine Production, R. Kelle, T. Hermann, and B. Bathe L-Tryptophan Production, M. Ikeda Synthesis of L-Threonine and Branched Chain Amino Acids, L.B. Willis, P. A. Lessard, and A. J. Sinskey Part VII: Experiments Experiments
713 citations
TL;DR: The growing market for amino acids produced with Corynebacteria led to significant improvements in bioprocess and downstream technology as well as in molecular biology, and one focus of this review is on recent developments in downstream technology.
621 citations