Topic
Cost effectiveness
About: Cost effectiveness is a research topic. Over the lifetime, 69775 publications have been published within this topic receiving 1531477 citations.
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TL;DR: Results clearly indicated that the high-risk subjects who received early intervention displayed statistically significant fewer indices of chronic pain disability on a wide range of work, healthcare utilization, medication use, and self-report pain variables, relative to the high risk subjects who do not receive such early intervention.
Abstract: In an attempt to prevent acute low-back pain from becoming a chronic disability problem, an earlier study developed a statistical algorithm which accurately identified those acute low-back pain patients who were at high risk for developing such chronicity. The major goal of the present study was to evaluate the clinical effectiveness of employing an early intervention program with these high-risk patients in order to prevent the development of chronic disability at a 1-year follow-up. Approximately 700 acute low-back pain patients were screened for their high-risk versus low-risk status. On the basis of this screening, high-risk patients were then randomly assigned to one of two groups: a functional restoration early intervention group (n = 22), or a nonintervention group (n = 48). A group of low-risk subjects (n = 54) who did not receive any early intervention was also evaluated. All these subjects were prospectively tracked at 3-month intervals starting from the date of their initial evaluation, culminating in a 12-month follow-up. During these follow-up evaluations, pain disability and socioeconomic outcomes (such as return-to-work and healthcare utilization) were assessed. Results clearly indicated that the high-risk subjects who received early intervention displayed statistically significant fewer indices of chronic pain disability on a wide range of work, healthcare utilization, medication use, and self-report pain variables, relative to the high-risk subjects who do not receive such early intervention. In addition, the high-risk nonintervention group displayed significantly more symptoms of chronic pain disability on these variables relative to the initially low-risk subjects. Cost-comparison savings data were also evaluated. These data revealed that there were greater cost savings associated with the early intervention group versus the no early intervention group. The overall results of this study clearly demonstrate the treatment- and cost-effectiveness of an early intervention program for acute low-back pain patients.
223 citations
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TL;DR: This brief review compares the 2 study designs as they relate to pharmacoeconomic evaluations in terms of the research questions they address, design differences and their implications for study bias, data collection and data analysis and the generalisability of their results.
Abstract: Pharmacoeconomic data may be obtained within the context of randomised clinical trials (RCTs) and from effectiveness studies in the 'real world'. The differences between the 2 types of study design have implications for the types of data that can be obtained and the interpretation of the resulting findings. Because RCTs are designed to assess the safety and efficacy of pharmaceuticals, and because the study design of RCTs emphasises internal validity over generalisability, the pharmacoeconomic data collected from them are limited. The data may not be applicable to the more heterogeneous patients encountered in actual clinical practice, and cost estimates may be inaccurate because of protocol requirements. Effectiveness studies, in which treatments are studied under real-world conditions, remedy some of these limitations. Generalisability to actual users is generally enhanced in effectiveness designs, but data may be biased in other ways. This brief review compares the 2 study designs as they relate to pharmacoeconomic evaluations in terms of the research questions they address, design differences and their implications for study bias, data collection and data analysis and the generalisability of their results.
223 citations
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TL;DR: The research shows that the RAB system is an efficient algal culture system for easy biomass harvest with enhanced biomass productivity.
223 citations
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TL;DR: Imperfect contraceptive adherence leads to substantial UP and high, avoidable costs, and improved uptake of LARC may generate health care cost savings by reducing contraceptive non-adherence.
223 citations
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TL;DR: A Markov simulation model was developed to compare different strategies for prophylaxis of Pneumocystis carinii pneumonia, toxoplasmosis, Mycobacterium avium complex (MAC) infection, fungal infections, and cytomegalovirus (CMV) disease in HIV-infected patients to determine the clinical impact, cost, and cost-effectiveness of strategies.
Abstract: Context.—Multiple options are now available for prophylaxis of opportunistic
infections related to the acquired immunodeficiency syndrome (AIDS). However,
because of differences in incidence rates as well as drug efficacy, toxicity,
and costs, the role of different types of prophylaxis remains uncertain.Objective.—To determine the clinical impact, cost, and cost-effectiveness of strategies
for preventing opportunistic infections in patients with advanced human immunodeficiency
virus (HIV) disease.Design.—We developed a Markov simulation model to compare different strategies
for prophylaxis of Pneumocystis carinii pneumonia
(PCP), toxoplasmosis, Mycobacterium avium complex
(MAC) infection, fungal infections, and cytomegalovirus (CMV) disease in HIV-infected
patients. Data for the model were derived from the Multicenter AIDS Cohort
Study, randomized controlled trials, and the national AIDS Cost and Services
Utilization Survey.Main Outcome Measures.—Projected life expectancy, quality-adjusted life expectancy, total lifetime
direct medical costs, and cost-effectiveness in dollars per quality-adjusted
life-year (QALY) saved.Results.—For patients with CD4 cell counts of 0.200 to 0.300×109/L
(200-300/µL) who receive no prophylaxis, we projected a quality-adjusted
life expectancy of 39.08 months and average total lifetime costs of $40288.
Prophylaxis for PCP and toxoplasmosis with trimethoprim-sulfamethoxazole for
patients with CD4 cell counts of 0.200×109/L (200/µL)
or less increased quality-adjusted life expectancy to 42.56 months, implying
an incremental cost of $16000 per QALY saved. Prophylaxis for MAC for patients
with CD4 cell counts of 0.050×109/L (50/µL) or less
produced smaller gains in quality-adjusted life expectancy; incremental cost-effectiveness
ratios were $35000 per QALY saved for azithromycin and $74000 per QALY saved
for rifabutin. Oral ganciclovir for the prevention of CMV infection was the
least cost-effective prophylaxis ($314000 per QALY saved). Results were most
sensitive to the risk of developing an opportunistic infection, the impact
of opportunistic infection history on long-term survival, and the cost of
prophylaxis.Conclusions.—The cost-effectiveness of prophylaxis against HIV-related opportunistic
infections varies widely, but prophylaxis against PCP or toxoplasmosis and
against MAC delivers the greatest comparative value. In an era of limited
resources, these results can be used to set priorities and explore new alternatives
for improving HIV patient care.
223 citations