Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
Papers published on a yearly basis
Papers
More filters
TL;DR: Electrophysiological recordings were made from neurons in the dorsal column nuclei which were activated by stimulation of muscle and cutaneous receptors in the neck of the rat, and 18 (8%) of the neck-responsive neuron in the medulla were shown to project rostrally to the thalamus.
4 citations
02 Jun 1999
TL;DR: This paper presents a computational model designed and developed in order to test the validity of the proposed circuit in [15], and the results of the computer simulations support the predictions.
Abstract: Experimental data recorded in cat in vivo offer a new picture of the cuneate nucleus Classically defined as a simple relay station, the cuneate nucleus is currently seen as a fundamental stage in somatosensory information processing Intracellular and extracellular recordings have revealed a complex circuitry established by cuneothalamic cells, interneurons and afferent fibers from the sensorimotor cortex As a result of electrophysiological work, some circuits have been hypothesized in order to explain the data In this paper we present a computational model designed and developed in order to test the validity of the proposed circuit in [15] The results of the computer simulations support the predictions
4 citations
TL;DR: The data implied that NO would modulate neuronal activity in the DRG and CN both after MNT, and pre-stimulation administration of L-NAME or 7-NI suppressed the amount of NPY release from the stimulated terminals and thus attenuated c-Fos expression in the CN.
Abstract: In this study, we investigated whether nitric oxide (NO) modulated injury-induced neuropeptide Y (NPY) releasing and c-Fos expression in the cuneate nucleus (CN) after median nerve transection (MNT). We first examined the temporal changes of neuronal nitric oxide synthase (nNOS) expression in the dorsal root ganglion (DRG) and CN after MNT. Following MNT, the amounts of nNOS-like immunoreactive (nNOS-LI) neurons in the DRG and CN significantly increased as compared with those of the sham-operated rats. Furthermore, 4 weeks after MNT, the increases of nNOS-LI neurons in the DRG and CN were attenuated by pre-emptive lidocaine treatment in a dose-dependent manner. Finally, 4 weeks after MNT, pre-stimulation administration of L-NAME (Nω-Nitro-l-arginine methyl ester) or 7-NI (7-nitroindazole) suppressed the amount of NPY release from the stimulated terminals and thus attenuated c-Fos expression in the CN. Our data implied that NO would modulate neuronal activity in the DRG and CN both after MNT.
4 citations
Journal Article•
4 citations
TL;DR: The input-output relationship of a nucleus is defined here as the total spike activity leaving the nucleus as a function of the total activity entering the nucleus measured over an appropriate time interval, and good agreement is found between the average IO curves generated from the evoked potential and pooled single cell measurements.
4 citations