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Cuneate nucleus

About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.


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Journal ArticleDOI
Chia-Chi Liao1, Hui-Xin Qi1, Jamie L. Reed1, Ha-Seul Jeoung1, Jon H. Kaas1 
TL;DR: Findings indicated that corticocuneate inputs increase during the functional recovery, but their functional role is uncertain.
Abstract: Recovery of responses to cutaneous stimuli in the area 3b hand cortex of monkeys after dorsal column lesions (DCLs) in the cervical spinal cord relies on neural rewiring in the cuneate nucleus (Cu) over time. To examine whether the corticocuneate projections are modified during recoveries after the DCL, we injected cholera toxin subunit B into the hand representation in Cu to label the cortical neurons after various recovery times, and related results to the recovery of neural responses in the affected area 3b hand cortex. In normal New World monkeys, labeled neurons were predominately distributed in the hand regions of contralateral areas 3b, 3a, 1 and 2, parietal ventral (PV), secondary somatosensory cortex (S2), and primary motor cortex (M1), with similar distributions in the ipsilateral cortex in significantly smaller numbers. In monkeys with short-term recoveries, the area 3b hand neurons were unresponsive or responded weakly to touch on the hand, while the cortical labeling pattern was largely unchanged. After longer recoveries, the area 3b hand neurons remained unresponsive, or responded to touch on the hand or somatotopically abnormal parts, depending on the lesion extent. The distributions of cortical labeled neurons were much more widespread than the normal pattern in both hemispheres, especially when lesions were incomplete. The proportion of labeled neurons in the contralateral area 3b hand cortex was not correlated with the functional reactivation in the area 3b hand cortex. Overall, our findings indicated that corticocuneate inputs increase during the functional recovery, but their functional role is uncertain.

2 citations

Journal ArticleDOI
TL;DR: It is hypothesized that the functional state of the brain stem inhibitory locomotor system can exert a modulating influence on the formation of the defensive behavior of animals.
Abstract: The dependence of the dominant form of the defensive behavior of white male mongrel rats on the functional state of the brain stem inhibitory locomotor system has been studied in chronic experiments. It was established that the electrolytic destruction of the inhibitory zones of the cuneate nucleus of the midbrain, the medial parabrachial nucleus, the central and great nuclei of the raphe leads to the dominance of active defensive reactions in animals in confrontations with partners. The opposite effect is exerted by local injection of kainic acid into these regions of the brainstem. It is hypothesized that the functional state of the brain stem inhibitory locomotor system can exert a modulating influence on the formation of the defensive behavior of animals.

2 citations

Journal Article
TL;DR: Although they can not be regarded functionally equivalent to the dendritic triadic arrangements in the thalamic nuclei, the cuneate axonal triads are likely to participate not only in distance dependent stimulus discrimination, but also in movement perception.
Abstract: Theoretical considerations are presented about the possible functional significance of special triadic synaptic arrangements in medial cuneate nucleus. Although they can not be regarded functionally equivalent to the dendritic triadic arrangements in the thalamic nuclei, the cuneate axonal triads are likely to participate not only in distance dependent stimulus discrimination, but also in movement perception.

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20234
20222
202115
20204
20195
20186