Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
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TL;DR: The present study correlated surface and depth activity in the cat by recording SEPs simultaneously from skull electrodes and from depth electrodes placed in the cervical posterior columns, cuneate nucleus, medial lemniscus, inferior cerebellar peduncle, ventral posterior thalamus, and sensory radiation.
Abstract: We have previously identified, with surface-recording techniques, four potentials (I, II, III, IV) preceding the cortical component of the somatosensory evoked potential (SEP) in the cat. In the present study, we correlated surface and depth activity in the cat by recording SEPs simultaneously from skull electrodes and from depth electrodes placed in the cervical posterior columns, cuneate nucleus, medial lemniscus, inferior cerebellar peduncle, ventral posterior thalamus, and sensory radiation. Latencies and amplitudes of surface- and depth-recorded potentials and their responses to repetitive stimulation were analyzed. Our findings indicate that: (1) component I originates in cervical posterior columns and nucleus cuneatus; (2) component II reflects postsynaptic activity in nucleus cuneatus, medial lemniscus, and inferior cerebellar peduncle; (3) component III-A probably originates in the cerebellar hemispheres; (4) component III-B consists of component III-A and superimposed activity in the ventral posterior thalamus and sensory radiation; and (5) component IV originates in the sensory radiation.
48 citations
TL;DR: The bulbar relay subserved by primary muscle afferents from the monkey's deep radial nerve was investigated by means of transganglionic labeling with wheatgerm agglutinin conjugated with horseradish peroxidase as well as by electrophysiological techniques.
48 citations
TL;DR: It is concluded that in the central nervous system a small elevation of the concentration of Ca2+ or of Mg2+ has a powerful postsynaptic depressant effect.
Abstract: Ca2+ and Mg2+ released from five-barrelled micropipettes by currents of 5 to 80 nA caused a deceleration of the firing rate of neurones discharging spontaneously, or excited by the simulataneous administration of glutamate or acetylcholine, in the cerebral cortex, cuneate nucleus and spinal cord. Excitation of cells in the cuneate nucleus, caused by stimulation of sense organs, was also suppressed by Ca2+ and Mg2+. Synaptic transmission of volleys, evoked by electrical stimulation, from thalamus to cortical cells, from superficial radial nerve to cells in the cuneate nucleus, and from ventral root via recurrent collaterals to Renshaw cells, was partially or completely blocked by Ca2+ and Mg2+ (60 to 200 nA). When given together, the depressant effect of the two ions summed. There was no evidence of enhanced synpatic transmission under the influence of Ca2+. It is concluded that in the central nervous system a small elevation of the concentration of Ca2+ or of Mg2+ has a powerful postsynaptic depressant effect.
47 citations
TL;DR: Results indicate that capsaicin-sensitive primary afferents and brain CRF receptors are part of the pathways and biochemical coding through which abdominal surgery activates PVN neurons 1 h post surgery.
47 citations
TL;DR: For the first time, postnatal nicotine exposure can lead to an increase in apoptotic markers in the brain, and in piglets, these effects showed regional and gender-specific differences, suggesting that passive, postnat nicotine exposure may be responsible for some neuropathological changes observed in infants dying from SIDS.
47 citations