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Cuneate nucleus

About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.


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Journal ArticleDOI
TL;DR: It is concluded that the inhibition in the cuneate nucleus of monkeys may be associated with information loss rather than with an increased signal to noise ratio.

44 citations

Journal ArticleDOI
TL;DR: In adult monkeys with dorsal rhizotomies extending from the second cervical (C2) to the fifth thoracic (T5) vertebrae, cortex deprived of its normal inputs regained responsiveness to inputs conveyed by intact peripheral afferents from the face, suggesting reorganizational limits in adult primate somatosensory cortex.

44 citations

Journal ArticleDOI
RC Collins, EM Santori, T Der, AW Toga, EW Lothman 
TL;DR: Results revealed no consistent relationship between the relative strength of a projection and the magnitude of metabolic change within its field and the nature, strength, and frequency of stimulation; the site and nature of anatomic projection; the effects of anesthesia; and the strength of sensory feedback associated with the induced behavior.
Abstract: The quantitative 14C-deoxyglucose (DG) autoradiographic technique has been used to study changes in cerebral metabolism during forelimb movements induced by graded stimulation of motor cortex Experiments were directed at studying basic physiologic and anatomic aspects of the metabolic changes Single shocks caused movement without metabolic change, whereas low-frequency trains caused seizures Repetitive high-frequency train stimuli of short duration (500 Hz for 20 msec) caused jerk movements coupled with DG uptake in pathways With stimulation of the forelimb motor zone at frequencies of 15-30/min there was prominent activation of cortical columns and strips in ipsilateral SI, SII, and MII, and contralateral MI and SI Higher frequencies (120/min) were required to cause significant changes in DG in subcortical circuits The most prominent changes occurred within a longitudinal corridor in dorsal thalamus and a ventral corridor in second-order sites in basal ganglia Metabolic activation also occurred in contralateral cerebellum, the cuneate nucleus, and dorsal horn of the cervical spinal cord Changes in these latter two sites were largely eliminated by removing feedback sensory activity Stimulation of the forelimb sensory zone activated different sites in caudatoputamen and thalamus but similar zones in midbrain and cerebellum The magnitude of the metabolic response in distant sites depended on the frequency of cortical stimulation Different frequency-response relationships in different sites seemed to reflect the nature of the cortical input as well as differential effects of anesthesia The pattern of the metabolic response was studied by comparing sites of activation with sites of the anatomic projections from motor and sensory cortical zones 3H- and 14C-labeled amino acids were used to map the site and relative strength of pathways Results revealed good correlation between the site of anatomic projection and the site of DG uptake but no consistent relationship between the relative strength of a projection and the magnitude of metabolic change within its field Changes in glucose utilization with metabolic mapping experiments depend on the nature, strength, and frequency of stimulation; the site and nature of anatomic projection; the effects of anesthesia; and the strength of sensory feedback associated with the induced behavior

44 citations

Journal ArticleDOI
TL;DR: The somatotopic distribution of dorsal column nuclear projections within the basilar pontine gray was examined in relation to the massive corticopontine projection system that emanates most heavily from motor and somatosensory cortex.
Abstract: The somatotopic distribution of dorsal column nuclear projections within the basilar pontine gray was examined in relation to the massive corticopontine projection system that emanates most heavily from motor and somatosensory cortex. The distribution patterns of these two systems were compared by combining autoradiographic and degeneration axonal tracing methods within individual animals. Stereotaxic injections of tritiated leucine (50 microCi/microliter) and lesions by aspiration were made in animals under ketamine hydrochloride anesthesia. The forelimb cortical injections (0.1-0.3 microliter) were centered in either sensory or motor cortical regions as determined by intracortical microstimulation and multiunit recording techniques. Because sensory and motor hindlimb cortical areas overlap extensively in the rat, hindlimb cortical injections (0.1-0.3 microliter) were limited to a single hindlimb sensorimotor cortical region. The corresponding contralateral dorsal column nucleus, cuneatus or gracilis, was then aspirated. A somatotopic distribution of fore- and hindlimb corticopontine fibers were found in discrete regions of the ipsilateral pontine gray. Hindlimb sensorimotor corticopontine fibers distributed caudal to forelimb projections. Similarly, pontine afferents from the dorsal column nuclei terminated somatotopically in the caudal half of the contralateral pontine gray in that gracilopontine fibers distributed caudal to cuneopontine fibers. Within individual animals, partially overlapping terminations were seen from nucleus cuneatus and the forelimb sensory cortical area as well as from nucleus gracilis and the hindlimb sensorimotor cortical area. No overlap existed in the pontine terminations from nucleus cuneatus and the forelimb motor cortical area.

43 citations

Journal ArticleDOI
TL;DR: Projections from the spinal cord and the dorsal column nuclei to the ventrobasal complex of the thalamus were studied in the rat by using double anterograde labeling strategy.
Abstract: Projections from the spinal cord and the dorsal column nuclei (DCN) to the ventrobasal complex of the thalamus (VB) were studied in the rat by using double anterograde labeling strategy. This strategy was based on the injection of 3H-leucine into the DCN and of wheat germ agglutinin conjugated to horseradish perexidase (WGA-HRP) into the spinal cord and their subsequent transport. Adjacent 30-μm-thick sections were then processed differentially for autoradiography or for HRP by using tetramethyl benzidine (TMB) as a chromogen. Similar areas of the ventrobasal complex were labeled, in adjacent sections, after a large injection of 3H-leucine into the DCN and when wheat germ agglutinin-HRP had been injected in any part of the spinal cord. If, however, a small injection of the radioactive tracer was centered in the gracile nucleus and compared with an injection of WGA-HRP placed in the lumbar enlargement of the cord, the rostral and dorsal portions of the lateral VB were labeled from both sources. On the other hand, if tritiated leucine was injected into the cuneate nucleus, and WGA-HRP placed in the cervical enlargement, then the caudal and ventral portions of the lateral VB demonstrated overlap of both labels. The present results show that, in the rat, areas of termination of both the spinothalamic tract and the lemniscal pathway originating from the DCN overlap in the lateral VB. This overlap is somatotopically organized, thus indicating that the same area of the VB receives somatic inputs from one particular part of the body through both pathways. These results are discussed in comparison to those of comparable studies performed in the cat and in the monkey and with reference to the electrophysiological data that have demonstrated that, in the rat VB, neurons responding to noxious stimulation are intermingled with neurons exclusively responding to non-noxious stimulation.

43 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20234
20222
202115
20204
20195
20186