Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
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TL;DR: Using immunocytochemical methods, glutamic acid decarboxylase (GAD)-immunoreactive boutons were demonstrated throughout the dorsal column nuclei of the cat brain and strongly indicate that gamma-aminobutyric acid (GABA) is the neurotransmitter that is responsible for the presynaptic inhibition in the dorsalcolumn nuclei.
33 citations
TL;DR: Slow, inexorable progression of lemniscal and thalamocortical axonal withdrawal is a neurodegenerative phenomenon likely to be a powerful inducement to compensatory long-term plasticity, a mechanism that can explain the long- term evolution of cortical reorganization and, with it, phantom sensations in spinal patients and amputees.
Abstract: The mechanisms responsible for long-term, massive reorganization of representational maps in primate somatosensory cortex after deafferentation are poorly understood. Sprouting of cortical axons cannot account for the extent of reorganization, and withdrawal of axons of deafferented brainstem and thalamic neurons, permitting expression of previously silent synapses, has not been directly demonstrated. This study is focused on the second of these. In monkeys, deafferented for two years by section of the cuneate fasciculus at the C1 level, there was extensive withdrawal of axon terminals from thalamus and cortex, detectable a decade before visible atrophy of their parent neuronal somata in the cuneate nucleus or thalamus. Slow, inexorable progression of lemniscal and thalamocortical axonal withdrawal is a neurodegenerative phenomenon likely to be a powerful inducement to compensatory long-term plasticity, a mechanism that can explain the long-term evolution of cortical reorganization and, with it, phantom sensations in spinal patients and amputees.
33 citations
TL;DR: It is concluded that only muscle afferents terminate in the external cuneate nucleus of cat with the method of transganglionic transport of horseradish peroxidase.
Abstract: Muscular and cutaneous afferents from distal forelimb distributed to the cuneate and external cuneate nuclei have been demonstrated in cat with the method of transganglionic transport of horseradish peroxidase. Injections of the same tracer were also done in ganglia C7 to T6 to demonstrate the afferents to these two nuclei. It is concluded that only muscle afferents terminate in the external cuneate nucleus. Afferents from paw and forearm occupy sequential territories in the medial part of the nucleus, which are only partly exclusive. Afferents from individual flexor muscles of forearm occupy distinct sites but their distributions overlap with those of forearm extensor muscles. In the external cuneate nucleus, the, distributions of afferents from individual muscles constitute integral parts of a segmental representation. In the cuneate nucleus, cutaneous afferents are located dorsally and terminate over cells of the “clusters”. Muscle afferents are distributed in ventral regions and are topographically arranged. They terminate over “reticular” regions.
33 citations
TL;DR: PICROTOXIN has been shown to antagonize specifically the inhibitory action of λ-aminobutyric acid as opposed to glycine on cells of the cuneate nucleus, either spontaneously active or excited by peripheral stimulation.
Abstract: PICROTOXIN has been shown to antagonize specifically the inhibitory action of λ-aminobutyric acid (GABA) as opposed to glycine (Gly) on cells of the cuneate nucleus, either spontaneously active or excited by peripheral stimulation1. Bicucul-line also seems to be a specific antagonist of the depressant action of GABA in several regions of the mammalian nervous system2, although probably not in others3.
33 citations
TL;DR: The localization of cell bodies and of the central terminal projections of extraocular muscle afferent neurons was examined in adult cats using transport of horseradish peroxidase and confirmed that primary afferent cell somata subserving extraocular Muscle proprioception are located within the medial portion of the ipsilateral trigeminal ganglion.
32 citations