Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
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TL;DR: The present results suggest that approximately 60% of the NADPH-d/NOS-IR neurons in the cuneate nucleus are interneurons containing GABA and/or glycine.
18 citations
TL;DR: The prolonged and moderately increased inhibition caused by local cooling is probably due to activation of such cells causing increased presynaptic depolarization.
Abstract: Inhibitory mechanisms in the dorsal column nuclei have been studied during local cooling. The inhibition of transmission of a cutaneous volley across the cuneate nucleus caused by a preceding volley to the same or a neighbouring cutaneous nerve was prolonged and slightly increased by a moderate (25–30o C) reduction of the cuneate temperature. The excitability of presynaptic fibres and of the postsynaptic cell membrane both decreased progressively with decreasing temperature. Presynaptic depolarization increased during moderate cooling (25–30o C) but disappeared when the temperature was reduced to about 20o C.
One type of interneurone in the cuneate nucleus showed a progressive disruption of the normal pattern of firing with a gradual increase in the initial latency. An other type showed an increase of the rate and duration of the discharges to a single afferent volley on cooling. The latter type was susceptible to stimulation at 10 per s or higher. The behaviour of the latter interneurones matched the increased and prolonged presynaptic depolarization. These cells may be interneurones in a presynaptic inhibitory pathway. The prolonged and moderately increased inhibition caused by local cooling is probably due to activation of such cells causing increased presynaptic depolarization.
18 citations
TL;DR: The present study carried out to analyze the topography of projections from external cuneate nucleus to the anterior and posterior lobes of the cerebellum and to investigate whether projections to the two lobes come from different cuneocerebellar neurons or from branching axons of the same cells.
18 citations
TL;DR: Brain stem projections from each of the L1–L6 lumbar dorsal root ganglia (DRGs) were investigated in adult rats following DRG injections of choleragenoid-horseradish peroxidase, revealing a somatotopic organization which was most prominent in the middle part of Gr.
Abstract: Brain stem projections from each of the L1–L6 lumbar dorsal root ganglia (DRGs) were investigated in adult rats following DRG injections of choleragenoid-horseradish peroxidase. All these DRGs projected throughout the rostrocaudal extent of the gracile nucleus (Gr). Labeling from L1–L6 DRGs was transported to successively more dorsomedial areas of Gr. Investigation of the Gr projections from the DRGs revealed a somatotopic organization which was most prominent in the middle part of Gr. The cuneate nucleus showed smaller projections from all investigated DRGs. Minor projections to the internal basilar nucleus, external cuneate nucleus, medial vestibular nucleus, ventral cochlear nucleus and trigeminal sensory nuclei were also found from some of the DRGs.
18 citations
TL;DR: The serotoninergic innervation of the dorsal column nuclei (DCN) was investigated in cats and owl monkeys with immunohistochemical methods and showed that the labeled fibers were thin and unmyelinated.
Abstract: The serotoninergic innervation of the dorsal column nuclei (DCN) was investigated in cats and owl monkeys (Aotus trivirgatus) with immunohistochemical methods. A dense network of serotonin-immunoreactive fibers was present in the reticular regions of DCN in cats, and in the pars triangularis of the cuneate nucleus and the peripheral and caudal regions of the gracile nucleus in owl monkeys. The cat's cluster regions and the monkey's rotund regions were more sparsely innervated. Electron microscopic examination showed that the labeled fibers were thin and unmyelinated. Vesicle-containing, terminal-like structures were small. They were in contact with dendrites, other terminals and cell bodies, but synapses were rare.
The results demonstrate that the serotoninergic projection to the DCN in both cats and owl monkeys is heterogeneously distributed in a pattern that is faithfully related to the cytoarchitectonic subdivisions of the DCN. The densely innervated reticular regions in the DCN of cats and the corresponding regions in monkeys are predominantly involved in the processing of sensory information to the cerebellum, either directly, or indirectly through projections to the inferior olive, pontine gray, tectum, pretectum, red nucleus, or zona incerta. Thus, the present findings suggest that the serotoninergic innervation of the DCN is primarily related to the DCN's involvement in motor functions. © 1993 Wiley-Liss, Inc.
18 citations