Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
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TL;DR: The transganglionic transport of horseradish peroxidase was used to determine the projection pattern within the cuneate nucleus of the 4 major nerves innervating the forepaw of the raccoon, a carnivore noted for its tactile and manipulative abilities.
16 citations
TL;DR: It is proposed that the selective depression of transmission from group I and II afferents at long intervals is mediated at least partly by monoaminergic pathways, in view of the similarity of the effects of conditioning stimulation of the cuneiform nucleus and of the brainstem Monoaminergic nuclei and by directly applied monoamines.
Abstract: The effects of short trains of electrical stimuli applied within the cuneiform nucleus and the subcuneiform region were examined on transmission from group I and group II muscle afferents to first-order spinal neurons. Variations in the effectiveness of transmission from these afferents were assessed from changes in the sizes of the monosynaptic component of extracellular field potentials evoked following stimulation of muscle nerves. Field potentials evoked from group II muscle afferents in the dorsal horn of the midlumbar and sacral segments and in the intermediate zone of the midlumbar segments were reduced when the test stimuli applied to peripheral nerves were preceded by conditioning stimulation of the cuneiform nucleus or the subcuneiform region. The depression occurred at conditioning-testing intervals of 20-400 ms, being maximal at intervals of 32-72 ms for dorsal horn potentials and 40-100 ms for intermediate zone potentials. At the shortest intervals, both group II and group I field potentials in the intermediate zone were depressed. Conditioning stimulation of the cuneiform nucleus depressed group II field potentials nearly as effectively as conditioning stimulation of the coerulear or raphe nuclei. We propose that the nonselective depression of transmission from group I and II afferents at short intervals is due to the activation of reticulospinal pathways by cells or fibers stimulated within the cuneiform area. We also propose that the selective depression of transmission from group II afferents at long intervals is mediated at least partly by monoaminergic pathways, in view of the similarity of the effects of conditioning stimulation of the cuneiform nucleus and of the brainstem monoaminergic nuclei and by directly applied monoamines (Bras et al. 1990). In addition, it might be caused by primary afferent depolarization mediated by non-monoaminergic fibers (Riddell et al. 1992).
16 citations
16 citations
TL;DR: The present findings support and extend previous electrophysiological and anatomical studies of CN in the rat and provide a detailed physiological description of the functional organization of CN that is necessary for subsequent understanding of thefunctional reorganization ofCN that may result following forelimb amputation.
16 citations
TL;DR: The results indicate that the main cuneate nucleus projections to the inferior olive and cerebellar anterior lobe originate from different populations of neurons with high specific locations within the nucleus.
16 citations