Topic
Cuneate nucleus
About: Cuneate nucleus is a research topic. Over the lifetime, 614 publications have been published within this topic receiving 24859 citations. The topic is also known as: cuneate nucleus of spinal cord.
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TL;DR: Results indicate that sensory and motor neurons associated with PC8 distribute in a distinct segmental pattern, indicating that the sensory information from PC8 could be transganglionically transported to the spinal dorsal horn and cuneate nucleus.
Abstract: Objectives This study was performed to investigate the innervations related to acupuncture point PC8 in rats using a neural tracing technique. Methods After 6 μL of 1% cholera toxin subunit B (CTB) was injected into the site between the second and third metacarpal bone in rats, a corresponding site to acupuncture point PC8 in the human body, CTB labelling was examined with immunofluorescence and immunohistochemistry in the dorsal root ganglia (DRG), spinal cord and brainstem. Results All CTB labelling appeared on the ipsilateral side of the injection. The labelled sensory neurons distributed from cervical (C) 6 to thoracic (T) 1 DRG, while the labelled motor neurons were located on the dorsolateral part of the spinal ventral horn ranging from the C 6 to T 1 segments. In addition, the transganglionically-labelled axonal terminals were found to be dense in the medial part of laminae 3–4 from C 6 to the T 1 spinal dorsal horn, as far as in the cuneate nucleus. Conclusions These results indicate that sensory and motor neurons associated with PC8 distribute in a distinct segmental pattern. The sensory information from PC8 could be transganglionically transported to the spinal dorsal horn and cuneate nucleus.
10 citations
TL;DR: The influence of corticofugal discharges on transmission of sensory information through the cuneate nucleus was determined to be inhibitory, for nerve-evoked field potentials in the cunate output pathway (medial lemniscus) were depressed during cortical epileptiform events.
10 citations
01 Jan 1985
TL;DR: Microelectrodes were used to record the extracellular activity of 80 single neurons of the main cuneate nucleus of raccoons anesthetized with either methoxyflurane or pentobarbital sodium, and the proportions of neurons falling into these categories did not vary significantly with the type of response to thalamic stimulation.
Abstract: (1)Microelectrodes were used to record the extracellular activity of 80 single neurons of the main cuneate nucleus (MCN) of raccoons anesthetized with either methoxyflurane or pentobarbital sodium. All 80 MCN neurons had peripheral receptive fields (RFs) that lay entirely on the glabrous surfaces of the forepaw and were responsive to light mechanical stimulation. Neurons were characterized according to the nature of their response to mechanical stimulation of their RFs, as well as to their response to electrical stimulation of the contralateral thalamic ventrobasal complex (VB). (2) All antidromically activated neurons (64% of sample) were histologically verified as falling within the clusters region of the MCN, while synaptically activated neurons (19% of sample), as well as neurons not responsive to VB stimulation (17% of sample), were located in both the clusters and the polymorphic regions. (3) Antidromically activated neurons typically responded with a single fixed-latency spike, although a few respo...
10 citations
TL;DR: It is suggested the majority of the SOM-IR neurons in the rat CN are CTNs and that they may be involved in modulation of somatosensory synaptic transmission.
9 citations
TL;DR: 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus, suggesting glutamate or a related amino-acid may be the neurotransmitter released by pyramidal tract neurones.
Abstract: Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of the pyramidal tract on 28 of 40 cells (70%). Thus, glutamate or a related amino-acid may be the neurotransmitter released by pyramidal tract neurones.
9 citations