Topic
Curcuma zedoaria
About: Curcuma zedoaria is a research topic. Over the lifetime, 753 publications have been published within this topic receiving 8399 citations.
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TL;DR: A self-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of Zedoary turmeric oil (ZTO), an essential oil extracted from the dry rhizome of Curcuma zedoaria, stored at 25 degrees C for at least 12 months is developed.
249 citations
TL;DR: These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents.
243 citations
TL;DR: In this article, the essential oil of C. zedoaria (Berg.) Rosc. (Zingiberaceae) was isolated using simultaneous steam distillation and solvent extraction apparatus and its fractions were prepared by silica gel column chromatography.
195 citations
TL;DR: Bioassay-directed fractionation of an EtOH extract of Curcuma zedoaria led to isolation of an active curcuminoid, which was identified as demethoxycurcumin (2) by comparison of its 1H and 13C NMR spectra with literature data and by direct comparison with synthetic material.
Abstract: Bioassay-directed fractionation of an EtOH extract of Curcuma zedoaria led to isolation of an active curcuminoid, which was identified as demethoxycurcumin (2) by comparison of its 1H and 13C NMR spectra with literature data and by direct comparison with synthetic material. Curcumin (1) and bisdemethoxycurcumin (3) were also obtained. Curcuminoids (1-3) were synthesized and demonstrated to be cytotoxic against human ovarian cancer OVCAR-3 cells. The observed CD50 values of 1, 2, and 3 were 4.4, 3.8, and 3.1 microg/mL, respectively. Three additional novel compounds, 3, 7-dimethylindan-5-carboxylic acid (4), curcolonol (5), and guaidiol (6), were also isolated from the EtOH extract. The structures and relative stereochemistry of 4-6 were determined by spectroscopic methods and X-ray crystallographic analysis.
194 citations
TL;DR: This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology, and botany, chemistry, traditional uses and pharmacological data of the plant.
Abstract: ObjectivesCurcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.
Key findings Research carried out using different in-vitro and in-vivo techniques of biological evaluation supports most of the claims.
Summary This review presents the botany, chemistry, traditional uses and pharmacological data of the plant.
171 citations