Showing papers on "Curcumin published in 1978"
TL;DR: Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity and the major biliary metabolites were glucuronides of tetrahydrocurcumin and hexahydrocURcumin.
Abstract: Curcumin labelled with deuterium and tritium was prepared. Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity. 2. Intravenous and intraperitoneal doses of [3H]curcumin were well excreted in the bile of cannulated rats. 3. The major biliary metabolites were glucuronides of tetrahydrocurcumin and hexahydrocurcumin. A minor biliary metabolite was dihydroferulic acid together with traces of ferulic acid. Metabolites were identified using chemical ionization mass spectrometry.
310 citations
01 Jan 1978
TL;DR: Curcumin, the colouring principle of turmeric, is one of the few colours remaining on the Swedish list of food additives and its increased use may be assumed and further studies on the fate of curcumin in the body therefore become important for an assessment of its possible toxicity.
Abstract: Curcumin, the colouring principle of turmeric, is one of the few colours remaining on the Swedish list of food additives and its increased use may be assumed. Further studies on the fate of curcumin in the body therefore become important for an assessment of its possible toxicity. In experiments on isolated rat liver perfused with semi-synthetic human blood it was found that 1 to 15% of the curcumin added to the blood appeared in the bile within 3 h. Altogether about 20% of the added curcumin could be recovered from bile and liver in these experiments. Incubation of isolated liver microsomes or hepatocytes with curcumin, in conc:s up to 10 μg/ml, showed that roughly 80% of the added curcumin disappeared in 30 min at 37°C.
4 citations