scispace - formally typeset
Search or ask a question

Showing papers on "Curcumin published in 1985"


Journal ArticleDOI
TL;DR: Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours.

610 citations


Journal ArticleDOI
TL;DR: The kinetics of the pH-dependant degradation of curcumin has been investigated and a plot of the rate constant against pH indicates the pKa values of the acid protons.
Abstract: The kinetics of the pH-dependant degradation of curcumin has been investigated. A plot of the rate constant against pH indicates the pKa values of the acid protons. The graph also indicates the complexity of the curcumin degradation.

447 citations





01 Jan 1985
TL;DR: In this paper, die chemische Umwandlung von Curcumin bei pH 7 wurde untersucht, und HPLC-and MS-analysen haben gezeigt, dass die meisten sekundaeren Produkte von Feruloylmethan stammen.
Abstract: Die chemische Umwandlung von Curcumin bei pH 7 wurde untersucht. Ferulasaeure und Feruloylmethan sind die ersten Abbaustufen des Curcumins. HPLC- und MS-Analysen haben gezeigt, dass die meisten sekundaeren Produkte von Feruloylmethan stammen. Sie koennen Fehler verursachen bei der spektrophotometrischen Bestimmung des Curcumin.

41 citations


01 Jan 1985
TL;DR: It is presented here that turmeric extract and curcumin isolated from it is highly cytotoxic to mammalian cells and is effective in reducing animal tumours, indicating its potential for use in cancer treatment.
Abstract: SUMMARY Anticancer activity of the rhizomes of turmeric was evaluated in vitro using tissue culture methods and in vivo in mice using Dalton’s lymphoma cells grown as ascites form. Turmeric extract inhibited the cell growth in Chinese Hamster Ovary (CHO) cells at a concentration of 0.4 mg/ml and was cytotoxic to lymphocytes and Dalton’s lymphoma cells at the same concentration. Cytotoxic effect was found within 30 min at room temperature (30°C). The active constituent was found to be ‘curcumin’ which showed cytotoxicity to lymphocytes and Dalton’s lymphoma cells at a concentration of 4 pg/ml. Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours. INTRdDUCTION Turmeric (Curcuma longa) is a common spice used daily in curries in South India. Moreover, turmeric has been prescribed for many ailments in Indian natural medicines [ 4 3. It is applied to fresh wounds and bruises and also acts as a counter-irritant in insect bites. Internally it is an anthelminthic. Turmeric paste is applied to facilitate the process of scabbing in chicken pox and small pox. It is also used in many urinary diseases, diseases of liver and in jaundice. Turmeric has been described as a cancer remedy in Indian natural medical literature. However, no systematic effect has been made to study its effects by modem techniques. We present here that turmeric extract and curcumin isolated from it is highly cytotoxic to mammalian cells and is effective in reducing animal tumours, indicating its potential for use in cancer treatment.

3 citations