Showing papers on "Curcumin published in 1986"
Journal Article•
TL;DR: In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo and produced a better anti- inflammatory response than placebo.
Abstract: A new model for evaluating nonsteroidal anti-inflammatory drugs (NSAIDs) is described. In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo.
314 citations
TL;DR: The reaction mechanisms are investigated and the order of the over-all degradation reactions and the half-lives of curcumin in different solvents and in the solid state are determined.
Abstract: The photodecomposition of curcumin when exposed to UV/visible radiation is studied. The main degradation products are identified. The reaction mechanisms are investigated and the order of the over-all degradation reactions and the half-lives of curcumin in different solvents and in the solid state are determined.
203 citations
TL;DR: There are still quite a large number of antimutagenic principles in the Indian diet that will modulate the activity of environmental mutagens in the form of dose-dependent decreases in mutagenicity of chili extract and capsaicin.
Abstract: Turmeric, which is one of the commonly used spices in Indian cooking, was tested for mutagenicity using the Ames test. The alcoholic extract of fresh or dried turmeric, its principal components, and pyrolyzed turmeric powder and curcumin were tested for mutagenicity in Salmonella typhimurium strains with and without metabolic activation. None of these were mutagenic in all the tester strains. Chilies (which are used with turmeric powder) and their principal alkaloid capsaicin were mutagenic in the TA 98 with S9 mixture. We tested curcumin, which is the principal component of turmeric, for its antimutagenic effect. It showed dose-dependent decreases in mutagenicity of chili extract and capsaicin. Also, we compared the antimutagenicity of curcumin with other known antioxidants, including BHA, vitamins E and C, and vegetable oils. These all showed dose-dependent decreases in mutagenicity of chili extract and capsaicin. These studies show that although there are few mutagenic principles in Indian food, there is still quite a large number of antimutagenic principles in the Indian diet that will modulate the activity of environmental mutagens.
89 citations
Journal Article•
TL;DR: In the in vitro system, curcumin caused a slight increase in the synthesis of PGI2, while ASA inhibited it, andCurcumin may, therefore, be preferable in patients prone to vascular thrombosis and requiring antiarthritic therapy.
Abstract: In vitro and ex vivo effects of 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (diferuloylmethane, curcumin) and acetylsalicylic acid (ASA) on the synthesis of prostacyclin (PGI2) and on platelet aggregation has been studied in rat. Both drugs inhibited adenosine diphosphate (ADP)-, epinephrine (adrenaline)- and collagen-induced platelet aggregation in monkey plasma. Pretreatment with ASA (25-100 mg/kg), but not curcumin (100-300 mg/kg), inhibited PGI2 synthesis in rat aorta. In the in vitro system, too, curcumin caused a slight increase in the synthesis of PGI2, while ASA inhibited it. Curcumin may, therefore, be preferable in patients prone to vascular thrombosis and requiring antiarthritic therapy.
82 citations
TL;DR: The results suggest that dietary components could offer effective defence mechanism against free radical induced lipid peroxidation which in turn may lead to cellular damage and eventually even to promotion of transformation.
52 citations
TL;DR: Curcumin concentration was determined in the swollen rhizome-like portions at the base of in vitro grown shoots of turmeric plantlets derived from callus, which provides a basis for the selection in the laboratory ofTurmeric plants high in curcumin.
12 citations
TL;DR: Escherichia coli of intestinal origin was grown in the presence of different fractions of turmeric and curcumin and the alcoholic extract inhibited gas formation without inhibiting the growth of the bacteria.
Abstract: Escherichia coli of intestinal origin was grown in the presence of different fractions of turmeric (Curcuma longa L.). Curcumin (the pigment of turmeric) and the alcoholic extract of turmeric inhibited gas formation without inhibiting the growth of the bacteria. Curcumin, which is also a constituent of the alcoholic extract, bound iron in the medium. This inhibited the formation of the enzyme formic hydrogenlyase which in turn inhibited gas formation, with acid accumulation and reduced glucose utilization.
4 citations